Polyphenols Rich Hibiscus Rosa Sinensis Linn. Petals Modulate Diabetic Stress Signaling Pathways in Streptozotocin-Induced Experimental Diabetic Rats

The study from 8 years ago demonstrated that Hibiscus rosa sinensis Linn. petals (EHRS), rich in polyphenols, have significant anti-diabetic effects in streptozotocin-induced diabetic rats. EHRS, containing eight potent phytochemicals, was administered at a dose of 25 mg/kg body weight, leading to normalized blood glucose, glycated hemoglobin, and toxicity markers, as well as improved antioxidant defense system. The treatment with EHRS also modulated gene expressions involved in diabetic stress signaling pathways, comparable to the effects of metformin. The study, which involved 6 rats per group, concluded that EHRS could ameliorate diabetic complications by improving antioxidant status, reducing lipid peroxidation, and modulating stress-related and survival signaling pathways, with histopathological liver studies supporting these findings. The significance of the results was accepted at p < 0.05.