Recovery Effects of Active Oxygen Scavengers on Murine Hair Follicle-Derived Keratinocyte Proliferation Suppressed by Androgen

August 1994 in “ Journal of dermatological science ”

Hiroya Masaki, Yuri Okano, Yukio Kitano

androgens testosterone dihydrotestosterone hair follicle-derived keratinocytes androgen receptor inhibitors cyproterone acetate spironolactone active oxygen scavengers superoxide dismutase catalase dimethyl sulfoxide ESR spin-trapping reagents superoxide anions hydrogen peroxide hydroxyl radicals DHT HFK SOD DMSO

TLDR Active oxygen scavengers can reverse the suppression of hair cell growth caused by androgens.

The document from 1994 investigated the effects of androgens and active oxygen scavengers on the proliferation of murine hair follicle-derived keratinocytes (HFK). It was found that androgens such as testosterone and dihydrotestosterone suppressed the proliferation of HFK, and this suppression could be abolished by androgen receptor inhibitors like cyproterone acetate and spironolactone. The study further examined the role of active oxygen scavengers in this process and discovered that substances like superoxide dismutase (SOD), catalase, dimethyl sulfoxide (DMSO), and ESR spin-trapping reagents could reverse the suppression of HFK proliferation caused by androgens. However, sodium azide (NaN3) was not effective. These results indicated that active oxygen species such as superoxide anions, hydrogen peroxide, and hydroxyl radicals were involved in the androgen-mediated suppression of HFK proliferation.

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