Recovery Effects of Active Oxygen Scavengers on Murine Hair Follicle-Derived Keratinocyte Proliferation Suppressed by Androgen

August 1994 in “ Journal of dermatological science ”

Hiroya Masaki, Yuri Okano, Yukio Kitano

androgens testosterone dihydrotestosterone hair follicle-derived keratinocytes androgen receptor inhibitors cyproterone acetate spironolactone active oxygen scavengers superoxide dismutase catalase dimethyl sulfoxide ESR spin-trapping reagents superoxide anions hydrogen peroxide hydroxyl radicals DHT HFK SOD DMSO

TLDR Active oxygen scavengers can reverse the suppression of hair cell growth caused by androgens.

The document from 1994 investigated the effects of androgens and active oxygen scavengers on the proliferation of murine hair follicle-derived keratinocytes (HFK). It was found that androgens such as testosterone and dihydrotestosterone suppressed the proliferation of HFK, and this suppression could be abolished by androgen receptor inhibitors like cyproterone acetate and spironolactone. The study further examined the role of active oxygen scavengers in this process and discovered that substances like superoxide dismutase (SOD), catalase, dimethyl sulfoxide (DMSO), and ESR spin-trapping reagents could reverse the suppression of HFK proliferation caused by androgens. However, sodium azide (NaN3) was not effective. These results indicated that active oxygen species such as superoxide anions, hydrogen peroxide, and hydroxyl radicals were involved in the androgen-mediated suppression of HFK proliferation.

View this study on doi.org →

Discuss this study in the Community →

Related Community Posts Join

6 / 1000+ results

community Diffuse hair loss and scalp biopsies

in Research 692 upvotes 4 months ago

Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

community A meta analysis of 18 popular hair loss treatments. An 2022 guide on efficacy. From finasteride and minoxidil to caffeine shampoo, saw palmetto and biotin. 96 Scientific References included.

in Research/Science 103 upvotes 2 years ago

Most hair loss treatments are ineffective; only finasteride, dutasteride, and minoxidil show effectiveness.

community UPDATE: The theory that explains everything. Please help me make this big!

in Research/Science 449 upvotes 3 years ago

Hair loss theory involves 3alpha-hydroxysteroid reductase (3AHD) converting DHT to androstenol. Discussion explores potential treatments and encourages more research.

community Dutasteride SAVES your hair follicles: MAJOR BS on people who say it destroyed their hair permanently.

in Finasteride/Dutasteride 158 upvotes 11 months ago

The conversation discusses the effectiveness of hair loss treatments, specifically finasteride and dutasteride. The conclusion is that dutasteride significantly reduces DHT levels and may be more effective than finasteride for long-term hair retention, with some users reporting personal experiences and side effects.

community Why is dht bad for scalp hair but good for hair on the rest of body?

in Satire 109 upvotes 1 year ago

The conversation discusses why DHT (dihydrotestosterone) negatively affects scalp hair but promotes growth elsewhere on the body. Various opinions include genetic predispositions, differences in hair follicle reactions to DHT, and the potential role of Omega-3 in reducing inflammation and promoting hair health.

community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

in Research/Science 65 upvotes 1 year ago

Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

Related Research

4 / 4 results

Progenic Hair Regrowth Treatment: The Use of Platelet-Released Growth Factors for Treating Androgenetic Alopecia by Activating Hair Follicle Stem Cells

research Progenic Hair Regrowth Treatment: The Use of Platelet-Released Growth Factors for Treating Androgenetic Alopecia by Activating Hair Follicle Stem Cells

August 2014 in “Journal of clinical & experimental dermatology research”

Platelet-released growth factors can treat hair loss by activating hair follicle stem cells, blocking certain pathways, and controlling inflammation and fibrosis.

research Fullerene Nanomaterials Potentiate Hair Growth

36 citations, June 2009 in “Nanomedicine”

Fullerene nanomaterials help hair grow faster and increase hair follicles.

research Substance P Prolongs Human Hair Growth In Vitro

8 citations, September 2003 in “Journal of dermatological science”

Substance P helps hair grow longer and faster.

research Towards a Molecular Understanding of Hair Loss and Its Treatment

236 citations, July 2001 in “Trends in Molecular Medicine”

Future hair loss treatments should aim to extend hair growth, reactivate resting follicles, reverse shrinkage, and possibly create new follicles, with gene therapy showing promise.