Graphene Oxide–IPDI–Ag/ZnO@Hydroxypropyl Cellulose Nanocomposite Films for Biological Wound-Dressing Applications

The document reports on the creation and evaluation of AGO@HPC nanocomposite films, which incorporate graphene oxide (GO) modified with isophorone diisocyanate (IPDI) and silver-coated zinc oxide nanoparticles (Ag/ZnO) into a hydroxypropyl cellulose (HPC) matrix for use in wound dressing. The films showed a 16.2% increase in tensile strength with just 0.5 wt% AGO addition and exhibited improved anti-ultraviolet and antibacterial properties against E. coli and S. aureus. In vivo testing on 20 male BALB/C mice, divided into four groups, indicated that the films stimulated immune function and accelerated wound healing without systemic toxicity. The study concluded that the AGO@HPC nanocomposite films are promising for antibacterial packaging and wound dressing applications, offering a safer alternative to antibiotics.