Graphene Oxide–IPDI–Ag/ZnO@Hydroxypropyl Cellulose Nanocomposite Films for Biological Wound-Dressing Applications

    September 2019 in “ ACS omega ”
    Yiwei Wang, Liujun Shi, Haoping Wu, Qingyang Li, Wei Hu, Zhenbao Zhang, Langhuan Huang, Jingxian Zhang, Dengjie Chen, Sui‐Ping Deng, Shaozao Tan, Zhuhua Jiang
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    Studysummary This study found that AGO@HPC nanocomposite films demonstrated enhanced mechanical, anti-ultraviolet, and antibacterial properties, suggesting potential for use in antibacterial packaging and wound-dressing applications.
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    The document reports on the creation and evaluation of AGO@HPC nanocomposite films, which incorporate graphene oxide (GO) modified with isophorone diisocyanate (IPDI) and silver-coated zinc oxide nanoparticles (Ag/ZnO) into a hydroxypropyl cellulose (HPC) matrix for use in wound dressing. The films showed a 16.2% increase in tensile strength with just 0.5 wt% AGO addition and exhibited improved anti-ultraviolet and antibacterial properties against E. coli and S. aureus. In vivo testing on 20 male BALB/C mice, divided into four groups, indicated that the films stimulated immune function and accelerated wound healing without systemic toxicity. The study concluded that the AGO@HPC nanocomposite films are promising for antibacterial packaging and wound dressing applications, offering a safer alternative to antibiotics.
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