Graphene Oxide–IPDI–Ag/ZnO@Hydroxypropyl Cellulose Nanocomposite Films for Biological Wound-Dressing Applications

    September 2019 in “ ACS omega ”
    Yiwei Wang, Liujun Shi, Haoping Wu, Qingyang Li, Wei Hu, Zhenbao Zhang, Langhuan Huang, Jingxian Zhang, Dengjie Chen, Sui‐Ping Deng, Shaozao Tan, Zhuhua Jiang
    Image of study
    TLDR The new nanocomposite films are stronger, protect against UV, speed up wound healing, and are antibacterial without being toxic.
    The document reports on the creation and evaluation of AGO@HPC nanocomposite films, which incorporate graphene oxide (GO) modified with isophorone diisocyanate (IPDI) and silver-coated zinc oxide nanoparticles (Ag/ZnO) into a hydroxypropyl cellulose (HPC) matrix for use in wound dressing. The films showed a 16.2% increase in tensile strength with just 0.5 wt% AGO addition and exhibited improved anti-ultraviolet and antibacterial properties against E. coli and S. aureus. In vivo testing on 20 male BALB/C mice, divided into four groups, indicated that the films stimulated immune function and accelerated wound healing without systemic toxicity. The study concluded that the AGO@HPC nanocomposite films are promising for antibacterial packaging and wound dressing applications, offering a safer alternative to antibiotics.
    Discuss this study in the Community →

    Cited in this study

    1 / 1 results