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research Hair Follicle Stem Cell Faith Is Dependent on Chromatin Remodeling Capacity Following Low-Dose Radiation

13 citations , December 2017 in “Stem cells”

This study found that in mice, low-dose irradiation causes stem cells in hair follicles to undergo chromatin alterations, which may eventually lead to long-term functional loss in tissues or organs.

research CXXC5: A novel regulator and coordinator of TGF-β, BMP and Wnt signaling

28 citations , November 2018 in “Journal of Cellular and Molecular Medicine”

This review discusses the role of the CXXC5 protein as a transcription factor and signaling coordinator, noting its involvement in embryonic development, tissue homeostasis, and diseases such as tumorigenesis, but reports no new experimental findings.

research Morphea: progress to date and the road ahead

50 citations , March 2021 in “Annals of Translational Medicine”

This study highlights the need for further research on dysregulated immune and fibrotic pathways in morphea to better understand its pathogenesis and develop new biomarkers and therapies.

research Investigation of hub genes and immune infiltration in androgenetic alopecia using bioinformatics analysis

November 2022 in “Annals of Translational Medicine”

This study identified four hub genes that are closely linked to the causative factors of androgenetic alopecia, suggesting potential diagnostic and therapeutic targets.

research Stress-sensing in the human greying hair follicle: Ataxia Telangiectasia Mutated (ATM) depletion in hair bulb melanocytes in canities-prone scalp

14 citations , October 2020 in “Scientific reports”

This study found that ATM protein plays a crucial role in protecting human hair follicle melanocytes from oxidative stress, which is linked to the greying of hair.

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community Why do you take finasteride instead of dutasteride and also vice versa

in Finasteride/Dutasteride 26 upvotes 9 months ago

Finasteride is preferred for its shorter half-life and FDA approval, while dutasteride is seen as more effective but not FDA-approved for hair loss. Many combine these with minoxidil for improved results, though side effects and effectiveness vary.

community Any positive responses for Diffuse Thinner with Retrograde using Fin/Min/Dut

4 upvotes 1 year ago

People with diffuse thinning and retrograde hair loss are discussing treatments like finasteride, minoxidil, and dutasteride, with some reporting improvements and others experiencing issues like scalp inflammation and increased sebum. Suggestions include addressing scalp inflammation, considering gut health, and possibly using topical antiandrogens or micro-needling.

community does finasteride regrow deadzone hairs?

in Finasteride/Dutasteride 23 upvotes 4 months ago

Finasteride is helping regrow hair in previously thinning areas, and the user plans to add minoxidil to enhance results. The user is considering increasing the finasteride dose to 1mg daily for better outcomes.

community Finasteride can revive up to 7 year old dead hair

in Research/Science 188 upvotes 1 year ago

Finasteride and minoxidil can revive hair dormant for up to 7 years, with microneedling enhancing regrowth. Users report significant hair regrowth even after long periods of baldness.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 140 upvotes 2 years ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

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