TLDR There might be a specific histone code for cellular quiescence, but more research is needed.
The document reviewed the role of histone modifications in cellular quiescence, a state where cells temporarily stop dividing. It examined how histone marks influence chromatin structure, gene expression, and chromosome arrangement during the transition into and out of quiescence, which is vital for processes like wound healing and stem cell maintenance. The review evaluated various model systems and histone marks, exploring whether a specific "histone code" exists for quiescence. It concluded by discussing emerging technologies that could provide deeper insights into the potential histone code for quiescence.
26 citations
,
December 2019 in “Stem Cell Reports” Proper tissue repair in adult skin requires specific histone hypomethylation.
299 citations
,
January 2018 in “Journal of Clinical Investigation” Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.
31 citations
,
April 2016 in “Nature communications” Certain signals are important for reducing specific chemical markers on hair follicle stem cells during rest periods, which is necessary for healthy hair growth.
191 citations
,
September 2011 in “Cell stem cell” Hair follicle stem cells use specific chromatin changes to control their growth and differentiation.
235 citations
,
January 2011 in “Journal of Clinical Investigation” Men with baldness due to androgenetic alopecia still have hair stem cells, but lack specific cells needed for hair growth.
1201 citations
,
January 2010 in “Science” Active and quiescent stem cells work together in mammals to maintain and repair tissues.
