TLDR Lgr5 and the vitamin D receptor are key in controlling skin inflammation and tumor risk in mice.
The study investigated the genetic factors affecting skin inflammation and tumor susceptibility in mice by analyzing crosses between tumor-resistant Mus spretus and susceptible Mus musculus strains. Researchers combined germline polymorphisms with gene expression data to identify expression patterns linked to inflammation, cell cycle control, and tumor susceptibility. Significant findings included the identification of Lgr5 as a potential master regulator of hair follicle fate and the vitamin D receptor's role in managing epidermal barrier function, inflammation, and tumor susceptibility, offering insights into the genetic architecture of these complex traits.
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October 2008 in “Nature Genetics” Lgr5 is a marker for active, long-lasting stem cells in mouse hair follicles.
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May 2007 in “Proceedings of the National Academy of Sciences” Vitamin D receptor is crucial for normal hair growth and preventing hair loss.
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July 2016 in “Cellular and Molecular Life Sciences” Genetic changes in mice help understand skin and hair disorders, aiding treatment development for acne and hair loss.
March 2024 in “Current issues in molecular biology” Personalized medicine in dermatology uses molecular biomarkers to improve diagnosis and treatment but needs further advancements for practical use.
September 2013 in “Experimental Dermatology” The document concluded that stem cells are crucial for skin repair, regeneration, and may help in developing advanced skin substitutes.
Ovol2 is crucial for hair growth and skin healing by controlling cell movement and growth.
Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.
