Genetic Architecture of Mouse Skin Inflammation and Tumor Susceptibility

The study investigated the genetic factors affecting skin inflammation and tumor susceptibility in mice by analyzing crosses between tumor-resistant Mus spretus and susceptible Mus musculus strains. Researchers combined germline polymorphisms with gene expression data to identify expression patterns linked to inflammation, cell cycle control, and tumor susceptibility. Significant findings included the identification of Lgr5 as a potential master regulator of hair follicle fate and the vitamin D receptor's role in managing epidermal barrier function, inflammation, and tumor susceptibility, offering insights into the genetic architecture of these complex traits.