Expression of Morphogens During Human Follicle Development In Vivo and a Model for Studying Follicle Morphogenesis In Vitro

    July 1993 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Karen A. Holbrook, Lynne T. Smith, Elizabeth D. Kaplan, Sharon A. Minami, Gregory P. Hebert, Robert Underwood
    TLDR Hair follicle development involves complex interactions between skin layers and cells, but many details are still unknown.
    The document discussed the process of hair follicle development, emphasizing the critical interactions between the fetal epidermis and specialized dermal cells. It highlighted that hair follicles are part of a composite structure involving mesenchymal cells, a basement membrane, and a fibrous sheath. The study of follicle morphogenesis provided insights into similar processes in other organs and structures. The research aimed to move beyond descriptive studies to understand the molecular and physical signals that initiate and regulate follicle development, including cell proliferation, differentiation, and maintenance. However, many questions about the specific stages and regions of epithelial-mesenchymal interactions remained unanswered.
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