Expression of Morphogens During Human Follicle Development In Vivo and a Model for Studying Follicle Morphogenesis In Vitro

July 1993 in “ The journal of investigative dermatology/Journal of investigative dermatology ”

Karen A. Holbrook, Lynne T. Smith, Elizabeth D. Kaplan, Sharon A. Minami, Gregory P. Hebert, Robert Underwood

hair follicle development fetal epidermis dermal cells mesenchymal cells basement membrane fibrous sheath follicle morphogenesis epithelial-mesenchymal interactions

Studysummary This article reviews the role of epithelial-mesenchymal interactions in hair follicle development and discusses the challenges of understanding the signals that regulate this complex process; it reports no new results.

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The document discussed the process of hair follicle development, emphasizing the critical interactions between the fetal epidermis and specialized dermal cells. It highlighted that hair follicles are part of a composite structure involving mesenchymal cells, a basement membrane, and a fibrous sheath. The study of follicle morphogenesis provided insights into similar processes in other organs and structures. The research aimed to move beyond descriptive studies to understand the molecular and physical signals that initiate and regulate follicle development, including cell proliferation, differentiation, and maintenance. However, many questions about the specific stages and regions of epithelial-mesenchymal interactions remained unanswered.

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