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    Did you mean Cystatin M/E?
    Glossary Cystatin M/E

    protein inhibiting enzymes that break down other proteins

    Cystatin M/E, also known as CST6, is a protein that acts as an inhibitor of cysteine proteases, enzymes that break down proteins. It plays a crucial role in skin and hair follicle development by regulating the activity of these enzymes, ensuring proper cell growth and differentiation. Deficiencies or mutations in CST6 have been linked to certain skin disorders and may contribute to hair loss conditions like alopecia.

    Research 10 of 81

    1. Cystatin M/E Is a High Affinity Inhibitor of Cathepsin V and Cathepsin L by a Reactive Site That Is Distinct from the Legumain-binding Site 2006 · 100 citations
    2. A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification 2002 · 66 citations
    3. Colocalization of Cystatin M/E and its Target Proteases Suggests a Role in Terminal Differentiation of Human Hair Follicle and Nail 2008 · 22 citations
    4. Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin Genetics in medicine · 2018 · 10 citations
    5. Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V Frontiers in Genetics · 2021 · 6 citations
    6. 190 Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin 2019
    7. Epidermal differentiation: The role of proteases and their inhibitors European Journal of Cell Biology · 2004 · 118 citations
    8. Serum Cystatin C levels in adolescent females: A comparative study between PCOS and Non-PCOS groups International Journal of Gynaecology Research · 2025
    9. Skin aging: mechanisms, evaluation, and rejuvenation The EMBO Journal · 2026
    10. A Mixture of Tocopherol Acetate and L-Menthol Synergistically Promotes Hair Growth in C57BL/6 Mice Pharmaceutics · 2020 · 7 citations
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