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    Did you mean Cystatin M/E?
    Glossary Cystatin M/E

    protein inhibiting enzymes that break down other proteins

    Cystatin M/E, also known as CST6, is a protein that acts as an inhibitor of cysteine proteases, enzymes that break down proteins. It plays a crucial role in skin and hair follicle development by regulating the activity of these enzymes, ensuring proper cell growth and differentiation. Deficiencies or mutations in CST6 have been linked to certain skin disorders and may contribute to hair loss conditions like alopecia.

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    1. Cystatin M/E Is a High Affinity Inhibitor of Cathepsin V and Cathepsin L by a Reactive Site That Is Distinct from the Legumain-binding Site 2006 · 100 citations
    2. A null mutation in the cystatin M/E gene of ichq mice causes juvenile lethality and defects in epidermal cornification 2002 · 66 citations
    3. Colocalization of Cystatin M/E and its Target Proteases Suggests a Role in Terminal Differentiation of Human Hair Follicle and Nail 2008 · 22 citations
    4. Deficiency of the human cysteine protease inhibitor cystatin M/E causes hypotrichosis and dry skin Genetics in medicine · 2018 · 10 citations
    5. Cystatin M/E Variant Causes Autosomal Dominant Keratosis Follicularis Spinulosa Decalvans by Dysregulating Cathepsins L and V Frontiers in Genetics · 2021 · 6 citations
    6. 190 Deficiency of the Human Cysteine Protease Inhibitor Cystatin M/E Causes Hypotrichosis and Dry Skin 2019
    7. Epidermal differentiation: The role of proteases and their inhibitors European Journal of Cell Biology · 2004 · 118 citations
    8. Serum Cystatin C levels in adolescent females: A comparative study between PCOS and Non-PCOS groups International Journal of Gynaecology Research · 2025
    9. Skin aging: mechanisms, evaluation, and rejuvenation The EMBO Journal · 2026
    10. A Mixture of Tocopherol Acetate and L-Menthol Synergistically Promotes Hair Growth in C57BL/6 Mice Pharmaceutics · 2020 · 7 citations
    11. Identification of differentially expressed genes in actinic keratosis samples treated with ingenol mebutate gel PLOS ONE · 2020 · 4 citations
    12. Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury bioRxiv (Cold Spring Harbor Laboratory) · 2023 · 2 citations
    13. Lab Quality Management and Methodology Indian Journal of Medical Biochemistry · 2015
    14. From Anti-Aging Medicine to Precision Healthspan Pharmacology: Evidence Domains, Monitoring Requirements, and Practical Boundaries International Journal on Science and Technology · 2026
    15. Unexpected Extensive Hair Whitening Following Baricitinib Treatment for Alopecia Universalis: A Case Report and Mechanistic Insights Cureus · 2024
    16. The Lysosomal Protease Cathepsin L Is an Important Regulator of Keratinocyte and Melanocyte Differentiation During Hair Follicle Morphogenesis and Cycling ˜The œAmerican journal of pathology · 2002 · 146 citations
    17. Distinct mechanisms for sebaceous gland self-renewal and regeneration provide durability in response to injury Cell Reports · 2023 · 46 citations
    18. Performance of an interferon-γ release assay-based test for cell-mediated immunity to SARS-CoV-2 Frontiers in Immunology · 2023 · 3 citations
    19. Efficacy of exosomes in acute kidney injury treatment and the associated mechanism (Review) Molecular Medicine Reports · 2025 · 1 citations
    20. Inherited ichthyoses/generalized Mendelian disorders of cornification European journal of human genetics · 2012 · 81 citations
    21. Analysis of the expression pattern of the carrier protein transthyretin and its receptor megalin in the human scalp skin and hair follicles: hair cycle-associated changes Histochemistry and cell biology · 2010 · 6 citations
    22. Mendelian randomization studies of testosterone exposure: A systematic review Steroids · 2025
    23. Circulating Androgen Concentrations and Risk of Incident Heart Failure in Older Men: The Cardiovascular Health Study Journal of the American Heart Association · 2022 · 14 citations
    24. Serum androgens and risk of atrial fibrillation in older men: The Cardiovascular Health Study Clinical cardiology · 2018 · 19 citations
    25. Comparative Proteomic Analysis in Scar-Free Skin Regeneration in Acomys cahirinus and Scarring Mus musculus Scientific Reports · 2020 · 13 citations
    26. Targeting host cell proteases as a potential treatment strategy to limit the spread of SARS‐CoV‐2 in the respiratory tract Pharmacology Research & Perspectives · 2020 · 15 citations
    27. Influence of Oxidative and/or Reductive Treatment on Human Hair (I): Analysis of Hair-Damage after Oxidative and/or Reductive Treatment Journal of oleo science · 2003 · 20 citations
    28. Laser Capture Microdissection Reveals Transcriptional Abnormalities in Alopecia Areata before, during, and after Active Hair Loss Journal of Investigative Dermatology · 2015 · 16 citations
    29. RETRACTED: Explore the genetic exposure to alopecia areata Skin Research and Technology · 2024 · 2 citations
    30. The Genetics of Acne Annals of Human Genetics · 2025