In Situ Labeling of DNA Reveals Interindividual Variation in Nuclear DNA Breakdown in Hair and May Be Useful to Predict Success of Forensic Genotyping of Hair

April 2011 in “ International journal of legal medicine ”

Sandra Szabo, Karin Jaeger, H. Fischer, Erwin Tschachler, Walther Parson, Leopold Eckhart

nuclear DNA DNA breakdown forensic genotyping Hoechst 33258 dye DNA remnants DNA extraction DNA amplification DNA degradation hair formation polymorphic trait in situ DNA labeling DNA dye DNA analysis

TLDR In situ DNA labeling in hair can help predict forensic DNA analysis success.

The study investigated the variability in nuclear DNA breakdown in hair and its impact on forensic genotyping success. By using Hoechst 33258 dye to label DNA in situ, researchers found that hair from different individuals showed varying levels of DNA remnants. This variability correlated with the amount of DNA that could be extracted and successfully amplified. The study concluded that the completeness of DNA degradation during hair formation is a polymorphic trait and that in situ DNA labeling could help predict the success of forensic DNA analysis in shed hair.

View this study on link.springer.com →

Discuss this study in the Community →

Related Community Posts Join

6 / 309 results

community Wtf have we been doing for the last 30 years

in Treatment 526 upvotes 3 days ago

Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

community My Theory Regarding a Cause and Cure for Androgenetic Alopecia

in Treatment 97 upvotes 4 years ago

Hair loss theory suggests imbalance between Vitamin D Receptor (VDR) and Androgen Receptor (AR) activation. Proposed treatment includes upregulating VDR, downregulating AR, and improving mitochondrial health.

community Medications that cause extra hair growth

in Research/Science 123 upvotes 1 year ago

The post discusses the side effects of various drugs causing excess hair growth, questioning why only minoxidil is used in the hair loss industry. The conversation includes users sharing their experiences and concerns about potential side effects of these drugs, with some preferring baldness over potential health risks.

community My son is 2 and already has my hairline. Is it too late for fin?

in Satire 873 upvotes 2 years ago

A user jokes about their 2-year-old son having their hairline and asks if it's too late for finasteride. Replies include humorous suggestions like growing a beard, working out, and hair transplants.

community My hair journey. 1.4 years on minoxidil and 6 months ago added micro-needling and finasteride which made a huge difference

in Progress Pictures 1067 upvotes 8 months ago

The user shared a 1.4-year hair growth journey using minoxidil and recently added micro-needling and finasteride, which significantly improved their hair. They also mentioned taking consistent photos for comparison and dermarolling once a week with a 1.5 mm needle.

community Minoxidil seems logistically impossible and impractical to use

in Minoxidil 136 upvotes 1 year ago

The post discusses concerns about the practicality of using Minoxidil foam for hair loss, including the frequency of application, preparation, coverage area, and drying time. Responses suggest that missing a dose isn't detrimental, it can be applied once a day, it works on all hair areas, and it doesn't need to be perfectly dry before application.

Related Research

1 / 1 results

In Situ Labeling of DNA Reveals Interindividual Variation in Nuclear DNA Breakdown in Hair and May Be Useful to Predict Success of Forensic Genotyping of Hair

research In Situ Labeling of DNA Reveals Interindividual Variation in Nuclear DNA Breakdown in Hair and May Be Useful to Predict Success of Forensic Genotyping of Hair

27 citations, April 2011 in “International journal of legal medicine”

In situ DNA labeling in hair can help predict forensic DNA analysis success.