Transglutaminase Activity Is Conserved in Stratified Epithelia and Skin Appendages of Mammals and Birds

    January 2023 in “ International journal of molecular sciences ”
    Attila Placido Sachslehner, Marta Surbek, Bahar Golabi … Leopold Eckhart
    Studysummary This study reveals that transglutaminase activity is widespread in integumentary structures of mammals and birds, suggesting it plays a significant role in the cornification of hard skin appendages like nails and feathers.
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    Research cited in this study 10

    1. Establishment of a Culture Model for the Prolonged Maintenance of Chicken Feather Follicles Structure In Vitro PloS one · 2022
    2. A Scarless Healing Tale: Comparing Homeostasis and Wound Healing of Oral Mucosa With Skin and Esophagus Frontiers in Cell and Developmental Biology · 2021
    3. Convergent Evolution of Cysteine-Rich Keratins in Hard Skin Appendages of Terrestrial Vertebrates Molecular biology and evolution · 2019
    4. Development of Hair Fibers Advances in experimental medicine and biology · 2018
    5. Evolution of Trichocyte Keratins Advances in experimental medicine and biology · 2018
    6. Mutations in Three Genes Encoding Proteins Involved in Hair Shaft Formation Cause Uncombable Hair Syndrome American journal of human genetics · 2016
    7. Trichohyalin-Like Proteins Have Evolutionarily Conserved Roles in the Morphogenesis of Skin Appendages Journal of Investigative Dermatology · 2014
    8. Cell Death by Cornification Biochimica et biophysica acta. Molecular cell research · 2013
    9. Ultrastructural Visualization of Cross-Linked Protein Features in Epidermal Appendages Journal of Cell Science · 1994
    10. Expression of Hair-Related Keratins in a Soft Epithelium: Subpopulations of Human and Mouse Dorsal Tongue Keratinocytes Express Keratin Markers for Hair, Skin, and Esophageal Types of Differentiation Experimental Cell Research · 1989