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research Transglutaminase-3 Enzyme: A Putative Actor in Human Hair Shaft Scaffolding?

30 citations , August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that TGase 3 may contribute to hair fiber scaffolding by forming specific isopeptide bonds between keratin intermediate filaments and keratin-associated proteins.

research Ultrahigh-Power Sonicator Lysis Enables Deep ProteomicProfiling of Hair Shafts for Fetal Growth Restriction Biomarker Discovery

November 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

This study developed a new method using ultrahigh-power sonication and mass spectrometry to improve protein extraction from hair shafts, identifying 239 differentially expressed proteins related to fetal growth restriction, which were validated as potential noninvasive biomarkers for perinatal diagnostics.

research Are the Meibomian glands “hair follicles without a hair shaft” ?

2 citations , September 2010 in “Acta Ophthalmologica”

The study concluded that all parts of the normal human Meibomian gland ductal system show signs of early keratinisation, supporting the idea that these glands are akin to "hair follicles without a hair shaft.

research Hair keratin pattern in human hair follicles grown in vitro

29 citations , April 2003 in “Experimental dermatology”

In this study, in vitro growth of human hair follicles did not alter hair keratin expression patterns, maintaining follicle integrity and proper keratinization similar to in vivo conditions.

research Characterization of the Human Hair Keratin–Associated Protein 2 (KRTAP2) Gene Family

52 citations , April 2012 in “Journal of Investigative Dermatology”

This study found that KRTAP2 proteins predominantly express in the hair shaft cortex of humans, interact with hair keratins, and play crucial roles in hair shaft keratinization.

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community Hair Shaft Diameter and Density Comparison

13 upvotes 4 weeks ago

The conversation discusses differences in hair shaft diameter and density between thinning and denser areas on the scalp. Treatments mentioned include Minoxidil, finasteride, and dutasteride.

community FDA Policy Shift Explained: What It Actually Means for PP405, VDPHL-01, Breezula and Hair Loss Drug Timelines

in Research/Science 42 upvotes 6 months ago

The FDA policy change may speed up approval for hair loss drugs like PP405, VDPHL-01, and Breezula by potentially eliminating the need for a second confirmatory Phase 3 trial. Approval timelines could be as early as 2028 for some treatments if Phase 3 results are strong.

community Recent trials investigating mesenchymal stem cell derived exosomes demonstrate significant increases in anagen duration and hair shaft caliber by upregulating Wnt/beta-catenin pathways.

4 upvotes 3 weeks ago

Exosomes from mesenchymal stem cells can increase hair growth by enhancing anagen duration and hair shaft thickness through the Wnt/beta-catenin pathway. Phase 2 trials show improved hair counts over 24 weeks.

community Microneedling must reach the stem cells in the upper hair shaft

82 upvotes 4 years ago

Microneedling should target depths of 0.5mm to 1.5mm for hair loss, with weekly sessions at 1mm recommended. Combining microneedling with Minoxidil is common for improved results.

community After using finasteride, did you notice an improvement in the hair shaft in terms of looking more “alive” and shiny?

2 upvotes 7 months ago

Finasteride users reported improvements in hair appearance, including increased thickness, shine, and darker color. Some users noticed their hair looked healthier and less sunburned after starting the treatment.

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Learn

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learn Cetirizine

How does cetirizine reduce inflammation linked to hair loss? Cetirizine is proposed to lower prostaglandin D2 and raise prostaglandin E2 around hair follicles; three small trials of a compounded 1% topical report modest increases in hair density and shaft thickness, with minoxidil doing better head-to-head. Topical cetirizine is off-label and unapproved for hair loss, and the evidence is too thin to call it effective or safe.

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Adenosine

nucleoside used for hair regrowth stimulant properties

learn Valproic acid

an anticonvulsant repurposed for hair loss via histone inhibition

learn Stemoxydine

chemical from L'Oreal that encourages hair to enter growth phase

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SMP Specialist
Hairo Fallas
Newark, NJ, United States

Hairo Fallas