Lef1 Contributes to the Differentiation of Bulge Stem Cells by Nuclear Translocation and Cross-Talk with the Notch Signaling Pathway

January 2013 in “ International Journal of Medical Sciences ”

Yi Zhang, Jin Yü, Chunying Shi, Yaqin Huang, Yun Wang, Yang Tian, Jin Yang

TLDR Lef1 helps stem cells become hair cells by interacting with specific signaling pathways.

This study explored the role of Lymphoid enhancer binding factor-1 (Lef1) in the differentiation of bulge stem cells (BSCs) during the hair growth cycle. Lef1 was found to be strongly expressed during the anagen phase and up-regulated during stem cell differentiation toward a hair fate. The study demonstrated that Lef1 promotes BSC differentiation by facilitating the nuclear translocation of β-catenin and activating downstream signaling molecules such as c-myc and jagged1. Additionally, the co-activation of the Wnt and Notch signaling pathways was observed, indicating that Lef1 plays a crucial role in directing BSCs to adopt a hair fate.

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