Loss of Epidermal Evi/Wls Results in a Phenotype Resembling Psoriasiform Dermatitis

    August 2013 in “ The Journal of Cell Biology ”
    Iris Augustin, Julia Christina Gross, Daniel Baumann, Claudia Korn, Gráinne Kerr, Tamara Grigoryan, Cornelia Mauch, Walter Birchmeier, Michael Boutros
    TLDR Lack of Evi in skin causes psoriasis-like symptoms in mice.
    The study investigated the role of Wnt proteins in skin homeostasis by creating a conditional knockout of the Wnt cargo receptor Evi in mice. Mice lacking Evi expression in the epidermis exhibited hair loss during the first hair cycle, reddish skin, and impaired skin barrier function, resembling human psoriasis. The absence of Evi led to up-regulation of inflammation-associated genes and immune cell infiltration, including an age-dependent depletion of dendritic epidermal T cells and infiltration of γδ low T cells. These findings highlighted the essential role of Wnt secretion in maintaining normal skin homeostasis and immune cell recruitment.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 60 results

      community A concise, easy-to-understand post on Androgenic Alopecia theory and its practical applications

      in Research/Science  92 upvotes 2 years ago
      The mechanism of Androgenic Alopecia and practical applications of treatments like Minoxidil, Finasteride, RU58841, dermarolling, scalp massages, anti-fungals, progesterone, estrogen, PPAR-γ activators, reducing oxidative stress, and scalp exercises. It explains why DHT is important in AA and how other factors might be involved such as hypoxia, increased DKK-1 expression, morphological changes to the scalp, skull growth during childhood/puberty, and blood flow.

      community Fats on your Head to Stop Hair Loss?

      in Research/Science  142 upvotes 10 months ago
      The conversation discusses the potential of long-chain unsaturated fatty acids, like oleic and linoleic acid, as an additional treatment for hair loss, which may inhibit the enzyme responsible for converting testosterone to DHT and promote hair growth. Users humorously suggest using oils topically and discuss other hair loss treatments, but the main focus is on the science behind fatty acids and their role in hair health.

      community New potential hair loss treatment (news release)

      in Treatment  186 upvotes 4 years ago
      New potential hair loss treatment uses molecules from hairy moles to stimulate follicle growth. Topical solution requires less frequent application, like Botox injections a few times per year.

    Similar Research

    5 / 1000+ results