TLDR Lack of Evi in skin causes psoriasis-like symptoms in mice.
The study investigated the role of Wnt proteins in skin homeostasis by creating a conditional knockout of the Wnt cargo receptor Evi in mice. Mice lacking Evi expression in the epidermis exhibited hair loss during the first hair cycle, reddish skin, and impaired skin barrier function, resembling human psoriasis. The absence of Evi led to up-regulation of inflammation-associated genes and immune cell infiltration, including an age-dependent depletion of dendritic epidermal T cells and infiltration of γδ low T cells. These findings highlighted the essential role of Wnt secretion in maintaining normal skin homeostasis and immune cell recruitment.
51 citations,
August 2013 in “The Journal of experimental medicine/The journal of experimental medicine” Loss of a specific protein in skin cells causes symptoms similar to psoriasis.
51 citations,
August 2013 in “The Journal of experimental medicine/The journal of experimental medicine” Loss of a specific protein in skin cells causes symptoms similar to psoriasis.
47 citations,
July 2013 in “Pharmacological Reviews” Regenerative pharmacology, which combines drugs with regenerative medicine, shows promise for repairing damaged body parts and needs more interdisciplinary research.
November 2023 in “Linköping University medical dissertations” Keratinocytes and adipose-derived stem cells can effectively heal difficult skin wounds.
2 citations,
January 2013 in “Elsevier eBooks” The document explains the genetic causes and characteristics of inherited hair disorders.
January 2019 in “Springer eBooks” Platelet-rich plasma therapy may have benefits and is generally safe, but more research is needed to confirm its effectiveness and safety.
