Meis1 Regulates Epidermal Stem Cells and Is Required for Skin Tumorigenesis

July 2014 in “ PloS one ”

Kazuhiro Okumura, Megumi Saito, Emiko Isogai, Yoshimasa Aoto, Tsuyoshi Hachiya, Yasubumi Sakakibara, Yoshihisa Katsuragi, Sachiko Hirose, Ryo Kominami, Ryo Goitsuka, Takuro Nakamura, Yuichi Wakabayashi

Meis1 epidermal stem cells hair follicles DMBA TPA tumorigenesis neoplastic transformation

Studysummary In this study, Meis1 was found to regulate epidermal homeostasis and act as a proto-oncogenic factor in skin tissues, with differences in expression patterns between normal and tumor cells.

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