Expression of Potential Dermal Progenitor Cell Markers in the Tumor and Stroma of Skin Adnexal Malignant and Benign Tumors

April 2019 in “ Stem cells international ”

Sven R. Quist, Maximilian Eckardt, André Kriesche, Harald Gollnick

CRABP1 Nestin Ephrin B2 basal cell carcinomas skin appendage tumours sebaceous adenomas sebaceous carcinomas eccrine sweat gland tumours hair follicle tumours BCCs

TLDR Markers CRABP1, Nestin, and Ephrin B2 are present in skin cancer environments and may influence their development.

The study investigated the expression of dermal progenitor cell markers CRABP1, Nestin, and Ephrin B2 in 45 basal cell carcinomas and 38 skin appendage tumors. These markers were found in both the intratumoral stroma and the invasive front of the tumors, suggesting their involvement in tumor microenvironment and mesenchymal cell plasticity. CRABP1 was present at the invasive margin and tumor-stroma interaction sites, Nestin was highly expressed in the stroma of low-grade tumors, and Ephrin B2 was upregulated in advanced tumors. The findings indicated that these markers play roles in the formation and progression of skin appendage tumors, providing insights into potential therapeutic targets.

View this study on hindawi.com →

Discuss this study in the Community →

Cited in this study

4 / 4 results

research Skin Cell Heterogeneity in Development, Wound Healing, and Cancer

211 citations , September 2018 in “Trends in cell biology”

Different types of skin cells play specific roles in development, healing, and cancer.

research Eph/Ephrin Signaling in Epidermal Differentiation and Disease

42 citations , February 2012 in “Seminars in Cell & Developmental Biology”

Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.

research Epidermal Stem Cell Diversity and Quiescence

168 citations , August 2009 in “EMBO molecular medicine”

Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.

research Dynamic Regulation of Retinoic Acid-Binding Proteins in Developing, Adult, and Neoplastic Skin Reveals Roles for β-Catenin and Notch Signaling

84 citations , December 2008 in “Developmental biology”

Retinoic acid-binding proteins in skin are regulated by β-catenin and Notch signalling.

2 / 2 results

research Hair Disorders

October 2018 in “Springer eBooks”

The document concludes that various hair disorders have different treatments, including medication, surgery, and addressing underlying causes.

research Culture of the Human Pilosebaceous Unit, Hair Follicle, and Sebaceous Gland

30 citations , May 2018 in “Experimental Dermatology”

The article concludes that developing in vitro models for human hair structures is important for research and reducing animal testing, but there are challenges like obtaining suitable samples and the models' limitations.