TLDR Markers CRABP1, Nestin, and Ephrin B2 are present in skin cancer environments and may influence their development.
The study investigated the expression of dermal progenitor cell markers CRABP1, Nestin, and Ephrin B2 in 45 basal cell carcinomas and 38 skin appendage tumors. These markers were found in both the intratumoral stroma and the invasive front of the tumors, suggesting their involvement in tumor microenvironment and mesenchymal cell plasticity. CRABP1 was present at the invasive margin and tumor-stroma interaction sites, Nestin was highly expressed in the stroma of low-grade tumors, and Ephrin B2 was upregulated in advanced tumors. The findings indicated that these markers play roles in the formation and progression of skin appendage tumors, providing insights into potential therapeutic targets.
211 citations
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May 2018 in “Trends in cell biology” Different types of skin cells play specific roles in development, healing, and cancer.
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October 2011 in “Seminars in Cell & Developmental Biology” Eph/ephrin signaling is important for skin cell behavior and could be targeted to treat skin diseases.
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January 1992 in “Bangladesh Journal of Animal Science” Camel skin has typical mammalian layers, with hair follicles, glands, and muscles, varying by body area.
