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This study found that hair follicle stem cell-derived secretome mitigated cell death, apoptosis, and inflammation while upregulating neurotrophic factors in astrocytes exposed to oxygen-glucose deprivation, an in vitro ischemic stroke model, suggesting potential therapeutic benefits in stroke recovery.

This study found that palmitoylethanolamide may stimulate allopregnanolone synthesis and reduce oxidative stress in astrocytes through PPAR-α activation, suggesting a neuroprotective role.

This study found that mouse astrocytes formed cell spheres on agarose surfaces, acquired stem cell-like features, and their derived stem cells effectively differentiated into neurons that helped regenerate damaged nerves.

This study found that nestin-expressing cells in the hair follicle bulge exhibit multipotent stem cell-like properties and can generate neural cells both in vitro and in vivo.

This article discusses the bi-compartmental organization of hair follicle stem cell niches for balancing stem cell cycling and organ growth and proposes similar structures may exist in other adult stem cell niches but reports no new experimental results.