Nestin as a Marker of Unipotent Epithelial Progenitor Cell Differentiation into Outer Root Sheath Keratinocytes in Embryonic and Adult Hair Follicles

    Yuta Baba, Saki Onishi-Sakamoto, Kaori Ide, Koji Nishifuji

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that nestin-expressing unipotent progenitor cells capable of differentiating into outer root sheath keratinocytes are present during hair follicle development and in adult hair follicles.
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    Research cited in this study 10

    1. Progenitor Cells Expressing Nestin, a Neural Crest Stem Cell Marker, Differentiate Into Outer Root Sheath Keratinocytes Veterinary Dermatology · 2019
    2. Hair Follicle: A Novel Source of Multipotent Stem Cells for Tissue Engineering and Regenerative Medicine Tissue Engineering Part B-reviews · 2012
    3. New Insights into the Role of Runx1 in Epithelial Stem Cell Biology and Pathology Journal of Cellular Biochemistry · 2012
    4. Multipotent Nestin-Expressing Stem Cells Capable of Forming Neurons Are Located in the Upper, Middle, and Lower Part of the Vibrissa Hair Follicle Cell Cycle · 2012
    5. The Hair Follicle as a Dynamic Mini-Organ Current Biology · 2009
    6. Chemotherapy Targets the Hair Follicle Vascular Network but Not the Stem Cells Journal of Investigative Dermatology · 2006
    7. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005
    8. Nascent Blood Vessels in the Skin Arise from Nestin-Expressing Hair-Follicle Cells Proceedings of the National Academy of Sciences · 2004
    9. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    10. Expression of Calcium-Binding S100 Proteins A4 and A6 in Regions of the Epithelial Sac Associated with the Onset of Hair Follicle Regeneration Journal of Investigative Dermatology · 2001

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