Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020

    October 2020 in “ Preprints.org ”
    Peter A. Everts, Kentaro Onishi, Prathap Jayaram, José Fábio Lana, and Kenneth Mautner
    TLDR Platelet-rich plasma shows promise in healing and treating musculoskeletal issues, but translating lab results to human treatments is challenging.
    The document reviewed the potential of platelet-rich plasma (PRP) as an adjunctive therapy in regenerative medicine, particularly for musculoskeletal and spinal disorders, osteoarthritis, and chronic wounds. It highlighted the role of platelet growth factors in wound healing and the challenges in translating in vitro and animal study outcomes to human clinical treatments. Recent advancements in PRP technology, including platelet dosing, leukocyte activities, and serotonin effects, were discussed, along with PRP's mechanisms in inflammation and angiogenesis. The review also covered the impact of certain drugs on PRP activity and the integration of PRP with rehabilitation protocols.
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