Platelet-Rich Plasma: New Performance Understandings and Therapeutic Considerations in 2020

    October 2020 in “ Preprints.org
    Peter A. Everts, Kentaro Onishi, Prathap Jayaram, José Fábio Lana, and Kenneth Mautner
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    Studysummary This review discusses recent advancements in platelet-rich plasma therapies for tissue repair and regenerative medicine, but reports no new clinical results, highlighting a need for translating research into human clinical protocols.
    Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
    The document reviewed the potential of platelet-rich plasma (PRP) as an adjunctive therapy in regenerative medicine, particularly for musculoskeletal and spinal disorders, osteoarthritis, and chronic wounds. It highlighted the challenges in translating in vitro and animal study outcomes to human clinical treatments. Recent advancements in PRP technology were discussed, focusing on platelet dosing, leukocyte activities, and serotonin effects on pain management. The review also covered PRP's role in inflammation, angiogenesis, and tissue repair, as well as the impact of certain drugs on PRP activity and the integration of PRP with rehabilitation protocols.
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