Regulation of Keratin 9 in Nonpalmoplantar Keratinocytes by Palmoplantar Fibroblasts Through Epithelial-Mesenchymal Interactions

    April 1999 in “ ˜The œjournal of investigative dermatology/Journal of investigative dermatology ”
    Yuji Yamaguchi, Satoshi Itami, Masahito Tarutani, Ko Hosokawa, Hiroyuki Miura, Kunihiko Yoshikawa
    TLDR Nonpalmoplantar skin cells can be made to express keratin 9 by interacting with palmoplantar fibroblasts.
    The study demonstrated that keratin 9 (K9) expression in nonpalmoplantar keratinocytes was regulated by signals from palmoplantar fibroblasts through epithelial-mesenchymal interactions. Nonpalmoplantar keratinocytes expressed K9 mRNA when cocultured with palmoplantar fibroblasts, and this was confirmed via immunohistochemistry and transplantation experiments. Papillary palmoplantar fibroblasts were more effective than reticular fibroblasts in inducing K9 expression. Grafting nonpalmoplantar epidermal sheets onto human sole wounds resulted in a palmoplantar phenotype with significant K9 expression, suggesting potential applications for treating palmoplantar wounds.
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