TLDR Nonpalmoplantar skin cells can be made to express keratin 9 by interacting with palmoplantar fibroblasts.
The study demonstrated that keratin 9 (K9) expression in nonpalmoplantar keratinocytes was regulated by signals from palmoplantar fibroblasts through epithelial-mesenchymal interactions. Nonpalmoplantar keratinocytes expressed K9 mRNA when cocultured with palmoplantar fibroblasts, and this was confirmed via immunohistochemistry and transplantation experiments. Papillary palmoplantar fibroblasts were more effective than reticular fibroblasts in inducing K9 expression. Grafting nonpalmoplantar epidermal sheets onto human sole wounds resulted in a palmoplantar phenotype with significant K9 expression, suggesting potential applications for treating palmoplantar wounds.
173 citations
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July 1995 in “Biochemical and biophysical research communications” Male hormones promote hair cell growth by using a growth factor from nearby skin cells.
125 citations
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August 1992 in “Development” The study demonstrated that adult vibrissa follicle dermal papillae could induce hair growth and follicle formation when implanted into small incisional cuts on rat ear pinnae. The resulting hair fibers were abnormally large and exhibited vibrissa-type characteristics, indicating that the papillae interacted with the wound epidermis to produce new follicles. Histological and immunohistochemical analyses showed that early follicle construction involved a significant presence of laminin and type IV collagen in the dermis. These findings suggested that adult rat papillae retained the ability to determine vibrissa specificity in induced follicles, similar to embryonic dermis.
28 citations
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April 1996 in “Cell biology international” Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.
