The Role of Lysophosphatidic Acid in the Physiology and Pathology of the Skin

    December 2018 in “ Life sciences ”
    Lei Li, Juan Su, Junchen Chen … Xiang Chen
    Studysummary This review discusses the role of lysophosphatidic acid in skin physiology and pathology, highlighting its significance in processes like wound healing and hair follicle development, but reports no new clinical findings.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 9

    1. Suppression of Wnt/β-Catenin Signaling by EGF Receptor Is Required for Hair Follicle Development Molecular Biology of the Cell · 2018
    2. Many Paths to Alopecia via Compromised Regeneration of Hair Follicle Stem Cells Journal of Investigative Dermatology · 2013
    3. A Missense Mutation Within the Helix Initiation Motif of the Keratin K71 Gene Underlies Autosomal Dominant Woolly Hair/Hypotrichosis Journal of Investigative Dermatology · 2012
    4. LPA-Producing Enzyme PA-PLA1α Regulates Hair Follicle Development by Modulating EGFR Signaling The EMBO Journal · 2011
    5. Non-Edg Family LPA Receptors: The Cutting Edge of LPA Research Journal of Biochemistry/˜The œjournal of biochemistry · 2011
    6. The Human Keratins: Biology And Pathology Histochemistry and Cell Biology · 2008
    7. Human Hair Growth Deficiency Is Linked to a Genetic Defect in the Phospholipase Gene LIPH Science · 2006
    8. Hard and Soft Principles Defining the Structure, Function, and Regulation of Keratin Intermediate Filaments Current Opinion in Cell Biology · 2002
    9. Mice With a Null Mutation of the TGFα Gene Have Abnormal Skin Architecture, Wavy Hair, and Curly Whiskers and Often Develop Corneal Inflammation Cell · 1993