Lysophospholipid Mediators in Health and Disease

November 2021 in “ Annual review of pathology ”

Kuniyuki Kano, Junken Aoki, Timothy Hla

lysophosphatidic acid LPA sphingosine-1-phosphate S1P LIPH gene P2Y5 receptor hair growth LPA signaling immune responses vascular development

Studysummary This review discusses the regulatory roles of lysophospholipids like LPA and S1P in diseases such as fibrosis, neuropathic pain, and cancer, but reports no new clinical results.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

The review article "Lysophospholipid Mediators in Health and Disease" discusses the roles of lysophospholipids, particularly lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), in various physiological and pathological processes. Key findings include the involvement of LPA in hair growth, with genetic defects in the LIPH gene linked to hair growth deficiencies and the role of LPA and its receptor P2Y5 in maintaining human hair growth. Additionally, LPA signaling is implicated in lymphocyte migration and immune responses, while S1P signaling is crucial for vascular development and immune cell positioning. The review highlights the therapeutic potential of targeting these pathways in diseases such as cancer, fibrosis, and immune disorders.

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Research cited in this study

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research Autotaxin–Lysophosphatidic Acid–LPA3 Signaling at the Embryo-Epithelial Boundary Controls Decidualization Pathways

44 citations , June 2017 in “The EMBO Journal”

This study reports that the autotaxin–LPA–LPA3 signaling pathway at the embryo-epithelial boundary plays a critical role in decidualization by up-regulating HB-EGF and COX-2 in the uterine epithelium.

Disease Causing Homozygous Variants in the Human Hairless Gene

Lysophospholipid Mediators in Health and Disease

Research cited in this study

research Autotaxin–Lysophosphatidic Acid–LPA3 Signaling at the Embryo-Epithelial Boundary Controls Decidualization Pathways

research Disease Causing Homozygous Variants in the Human Hairless Gene

research Novel Lysophospholipid Receptors: Their Structure and Function

research LPA-Producing Enzyme PA-PLA1α Regulates Hair Follicle Development by Modulating EGFR Signaling

research Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, P2Y5/LPA6

research Disruption of P2RY5, an Orphan G Protein–Coupled Receptor, Underlies Autosomal Recessive Woolly Hair

research Human Hair Growth Deficiency Is Linked to a Genetic Defect in the Phospholipase Gene LIPH