Lysophospholipid Mediators in Health and Disease
January 2022
in “
Annual review of pathology
”
TLDR Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.
The review article "Lysophospholipid Mediators in Health and Disease" discusses the roles of lysophospholipids, particularly lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), in various physiological and pathological processes. Key findings include the involvement of LPA in hair growth, with genetic defects in the LIPH gene linked to hair growth deficiencies and the role of LPA and its receptor P2Y5 in maintaining human hair growth. Additionally, LPA signaling is implicated in lymphocyte migration and immune responses, while S1P signaling is crucial for vascular development and immune cell positioning. The review highlights the therapeutic potential of targeting these pathways in diseases such as cancer, fibrosis, and immune disorders.
