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GlossaryLysophosphatidic Acid

bioactive lipid influencing cell growth and hair regeneration

Lysophosphatidic Acid (LPA) is a bioactive lipid molecule that plays a crucial role in various biological processes, including cell growth, survival, and migration. It acts by binding to specific receptors on cell surfaces, triggering signaling pathways that can influence tissue repair, inflammation, and even hair growth.

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research Autotaxin–Lysophosphatidic Acid–LPA3 Signaling at the Embryo-Epithelial Boundary Controls Decidualization Pathways

44 citations, June 2017 in “The EMBO Journal”

LPA3 signaling in the uterus is crucial for placental formation and fetal development.

research LPA3, A Unique G Protein-Coupled Receptor For Lysophosphatidic Acid

31 citations, October 2010 in “Progress in lipid research”

LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.

research The Role of Lysophosphatidic Acid in the Physiology and Pathology of the Skin

24 citations, December 2018 in “Life sciences”

Lysophosphatidic acid is important for skin health and disease, and could be a target for new skin disorder treatments.

research Lysophosphatidic Acid and Signaling in Sensory Neurons

20 citations, January 2015 in “Biochimica and biophysica acta. Molecular and cell biology of lipids”

Lysophosphatidic acid affects sensory neurons and may cause neuropathic pain and itch.

research Generalized Pruritus in Primary Sclerosing Cholangitis: Implications of Histamine Release by Lysophosphatidic Acid

5 citations, June 2015 in “British Journal of Dermatology”

A certain medication improved severe itching in a boy with liver and bowel disease by reducing histamine levels, suggesting a new treatment target.

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