Identification and Characterization of a Novel Lysophosphatidic Acid Receptor, P2Y5/LPA6

The study identified p2y5 as a novel lysophosphatidic acid (LPA) receptor, which they proposed to designate as LPA6. This receptor was shown to couple with the G13-Rho signaling pathway, as demonstrated in "LPA receptor-null" RH7777 and B103 cells expressing p2y5, which exhibited LPA binding and Rho-dependent changes in cell morphology. The research also indicated that 2-acyl-LPA had higher activity on p2y5 compared to 1-acyl-LPA. Additionally, LPA-induced contraction in human umbilical vein endothelial cells was reduced by knocking down p2y5 with small interfering RNA. Importantly, a recent study suggested that p2y5 was essential for human hair growth, supporting its role as a functional LPA receptor.