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GlossaryLipoprotein(a) (LPA)

genetic risk factor for cardiovascular diseases due to arterial plaque buildup

Lipoprotein(a), often abbreviated as Lp(a), is a type of lipoprotein found in the blood that consists of an LDL (low-density lipoprotein) particle attached to a specific protein called apolipoprotein(a). Elevated levels of Lp(a) are considered a genetic risk factor for cardiovascular diseases, such as heart attacks and strokes, because they can contribute to the buildup of plaques in arteries.

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research Non-Edg Family LPA Receptors: The Cutting Edge of LPA Research

68 citations, July 2011 in “Journal of Biochemistry/The journal of biochemistry”

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.

research Autotaxin-LPA Signaling Contributes to Obesity-Induced Insulin Resistance in Muscle and Impairs Mitochondrial Metabolism

45 citations, August 2018 in “Journal of Lipid Research”

Blocking the ATX-LPA pathway may improve insulin sensitivity and mitochondrial function in obesity.

research LPA3, A Unique G Protein-Coupled Receptor For Lysophosphatidic Acid

31 citations, October 2010 in “Progress in lipid research”

LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.

research Segregation of Incomplete Achromatopsia and Alopecia Due to PDE6H and LPAR6 Variants in a Consanguineous Family from Pakistan

9 citations, July 2016 in “Genes”

Genetic variants in PDE6H and LPAR6 cause vision impairment and hair loss in two Pakistani brothers.

research Lysophospholipid Mediators in Health and Disease

49 citations, November 2021 in “Annual review of pathology”

Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.

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