253 citations
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April 2009 in “Journal of Biological Chemistry” This study found that p2y5 functions as a novel LPA receptor involved in the G13-Rho signaling pathway, with implications for human hair growth, and proposes renaming it to LPA6.
151 citations
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August 2011 in “The EMBO Journal” The enzyme PA-PLA1α is important for proper hair follicle development.
68 citations
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July 2011 in “Journal of Biochemistry/The journal of biochemistry” This review discusses newly identified non-Edg family lysophosphatidic acid receptors, detailing their roles in vascular development, platelet activation, and hair growth, and reports no clinical results.
3 citations
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September 2025 in “Neural Regeneration Research” Prostaglandins (PGs) are crucial in the immunomodulation of the nervous system, impacting neuroinflammation, neuroprotection, and neurodegeneration. They play dual roles, with some PGs exacerbating conditions like stroke and multiple sclerosis by promoting inflammation, while others offer neuroprotective effects. In diseases such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis, PG dysregulation is linked to disease progression. PGs also modulate immune responses in autoimmune neurological diseases and have complex roles in cerebrovascular diseases. Despite their therapeutic potential, the complexity of PG pathways and reliance on rodent models present challenges, necessitating further research to develop effective treatments.
2 citations
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January 2019 in “Medizinische Genetik” Among families with pediatric brain disease, this study identified over 200 novel genetic causes, revealing potential treatment points using drug repurposing or nutritional supplementation.