TLDR LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.
Lysophosphatidic acid (LPA) played a role in various physiological and pathological processes, including hair growth, through its interaction with G protein-coupled receptors (GPCRs). Among the six identified LPA receptors, LPA(3) was unique due to its activation by a specific form of LPA and its limited expression in reproductive organs. Studies using LPA(3)-deficient mice highlighted the receptor's crucial role in embryo implantation and revealed a genetic link between LPA and prostaglandin signaling. The review also discussed the importance of specific agonists and antagonists for each LPA receptor in studying LPA signaling functions.
253 citations
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April 2009 in “Journal of Biological Chemistry” p2y5, now called LPA6, is a receptor important for human hair growth.
210 citations
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February 2008 in “Nature genetics” Mutations in the P2RY5 gene cause autosomal recessive woolly hair.
194 citations
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November 2006 in “Science” A genetic mutation in the LIPH gene causes hair loss and growth defects.
253 citations
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April 2009 in “Journal of Biological Chemistry” p2y5, now called LPA6, is a receptor important for human hair growth.
158 citations
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June 2014 in “Journal of Lipid Research” Lysophospholipids can act as anti-inflammatory agents through specific receptors, but more research is needed.
151 citations
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August 2011 in “The EMBO Journal” The enzyme PA-PLA1α is important for proper hair follicle development.
57 citations
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May 2014 in “Molecular Phylogenetics and Evolution” The research found how GPCR Class A Rhodopsin receptors are related and suggested possible substances they interact with.
68 citations
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July 2011 in “Journal of Biochemistry/The journal of biochemistry” New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.
