LPA3, A Unique G Protein-Coupled Receptor For Lysophosphatidic Acid

October 2010 in “ Progress in lipid research ”

Kotaro Hama, Junken Aoki

lysophosphatidic acid LPA G protein-coupled receptors GPCRs LPA3 LPA receptors prostaglandin signaling agonists antagonists

TLDR LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.

Lysophosphatidic acid (LPA) played a role in various physiological and pathological processes, including hair growth, through its interaction with G protein-coupled receptors (GPCRs). Among the six identified LPA receptors, LPA(3) was unique due to its activation by a specific form of LPA and its limited expression in reproductive organs. Studies using LPA(3)-deficient mice highlighted the receptor's crucial role in embryo implantation and revealed a genetic link between LPA and prostaglandin signaling. The review also discussed the importance of specific agonists and antagonists for each LPA receptor in studying LPA signaling functions.

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