TLDR LPA3 is crucial for embryo implantation and links LPA to prostaglandin signaling.
Lysophosphatidic acid (LPA) played a role in various physiological and pathological processes, including hair growth, through its interaction with G protein-coupled receptors (GPCRs). Among the six identified LPA receptors, LPA(3) was unique due to its activation by a specific form of LPA and its limited expression in reproductive organs. Studies using LPA(3)-deficient mice highlighted the receptor's crucial role in embryo implantation and revealed a genetic link between LPA and prostaglandin signaling. The review also discussed the importance of specific agonists and antagonists for each LPA receptor in studying LPA signaling functions.
210 citations,
February 2008 in “Nature genetics” Mutations in the P2RY5 gene cause autosomal recessive woolly hair.
194 citations,
November 2006 in “Science” A genetic mutation in the LIPH gene causes hair loss and growth defects.
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49 citations,
November 2021 in “Annual review of pathology” Lysophospholipids like LPA and S1P are important for hair growth, immune responses, and vascular development, and could be targeted for treating diseases.
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57 citations,
May 2014 in “Molecular Phylogenetics and Evolution” The research found how GPCR Class A Rhodopsin receptors are related and suggested possible substances they interact with.
68 citations,
July 2011 in “Journal of Biochemistry/The journal of biochemistry” New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.
44 citations,
June 2017 in “The EMBO Journal” LPA3 signaling in the uterus is crucial for placental formation and fetal development.
Finding functions for unknown GPCRs is hard but key for making new drugs.
