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Glossary Ionizing Radiation

high-energy particles or waves that can remove electrons from atoms

Ionizing radiation (IR) refers to high-energy particles or waves, such as X-rays, gamma rays, and certain particles, that have enough energy to remove tightly bound electrons from atoms, creating ions. This process can damage or alter the DNA in cells, which is why it is used in medical imaging and cancer treatment, but also why it poses risks such as radiation sickness and increased cancer risk with excessive exposure.

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Cell and Tissue Damage After Skin Exposure to Ionizing Radiation: Short- and Long-Term Effects After Single and Fractional Doses

research Cell and Tissue Damage after Skin Exposure to Ionizing Radiation: Short- and Long-Term Effects after a Single and Fractional Doses

14 citations , January 2014 in “Cells Tissues Organs”

This study found that single high-dose irradiation in mice induced more severe acute skin injury and hair depigmentation, while fractional doses led to longer-term damage in the dermis and subcutis.

research Cultured Human Foreskin as a Model System for Evaluating Ionizing Radiation-Induced Skin Injury

4 citations , August 2022 in “International Journal of Molecular Sciences”

This study found that cultured foreskin is not suitable for studying H2A.J-related tissue changes during radiation-induced dermatitis due to existing high H2A.J expression and cytokine secretion even without irradiation.

research Keratin 17 Impacts Global Gene Expression and Controls G2/M Cell Cycle Transition in Ionizing Radiation–Induced Skin Damage

3 citations , July 2023 in “The journal of investigative dermatology/Journal of investigative dermatology”

In this study, researchers found that K17−/− mice suffered more severe hair follicle damage but showed reduced epidermal inflammation after ionizing radiation, with K17's absence leading to aberrant cell cycle progression due to altered p53 genome binding and reduced B-Myb degradation.

research A Therapeutic Role for Survivin in Mitigating the Harmful Effects of Ionizing Radiation

2 citations , January 2016 in “Sarcoma”

This study found that using a recombinant adenoassociated virus to induce survivin expression protected normal tissues from radiation damage in mice, reducing side effects compared to controls.

research Effects of Ionizing Radiation on Murine Gene Expression in Skin and Bone

January 2017 in “NASA Technical Reports Server (NASA)”

This study suggests that radiation-induced changes in FGF18 gene expression in the skin may predict later reductions in bone mass, as observed in irradiated mice.

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community Doctor won’t put me on fin or dut until my wife gives birth. Is this normal?

10 upvotes 2 years ago

A doctor advised against using finasteride or dutasteride during pregnancy. The user continues with oral and topical minoxidil, microneedling, tretinoin, Nizoral, and pyrilutamide.

community Making your own RT1640 in China

4 years ago

RT1640, a combination of cyclosporin A, minoxidil, and RT175, is discussed as a potential treatment for hair regrowth and repigmentation. The unique formulation aims to enhance hair follicle growth and restore hair pigment without the negative side effects of immunosuppressants.

community Sexual Sides? Are you sure you don't masturbate too much?

13 upvotes 9 years ago

Finasteride can cause sexual side effects, and reducing porn and masturbation may help improve sexual function. Some users experience persistent issues even after stopping finasteride.

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