14 citations
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January 2014 in “Cells Tissues Organs” This study found that single high-dose irradiation in mice induced more severe acute skin injury and hair depigmentation, while fractional doses led to longer-term damage in the dermis and subcutis.
4 citations
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August 2022 in “International Journal of Molecular Sciences” This study found that cultured foreskin is not suitable for studying H2A.J-related tissue changes during radiation-induced dermatitis due to existing high H2A.J expression and cytokine secretion even without irradiation.
3 citations
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July 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that K17−/− mice suffered more severe hair follicle damage but showed reduced epidermal inflammation after ionizing radiation, with K17's absence leading to aberrant cell cycle progression due to altered p53 genome binding and reduced B-Myb degradation.
2 citations
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January 2016 in “Sarcoma” This study found that using a recombinant adenoassociated virus to induce survivin expression protected normal tissues from radiation damage in mice, reducing side effects compared to controls.
January 2017 in “NASA Technical Reports Server (NASA)” This study suggests that radiation-induced changes in FGF18 gene expression in the skin may predict later reductions in bone mass, as observed in irradiated mice.
September 2022 in “Journal of Theoretical Biology” This study developed a mathematical model to explore hair follicle regeneration mechanisms, showing that low spontaneous apoptosis rates help regenerate hair follicles after ionizing radiation, while high rates lead to degeneration during the catagen phase.
April 2017 in “Journal of Investigative Dermatology” This study found that anagen hair follicles can quickly regenerate after radiation damage by forming new progenitor cells outside the bulge, bypassing the need for telogen entry.
5 citations
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May 1957 in “Nature” 
April 2018 in “Radiotherapy and Oncology” Mitochondria may influence how cells respond to radiation, affecting nearby non-irradiated cells.
38 citations
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September 2017 in “Cancer Research” This study reports that hair follicles can mobilize ectopic progenitors for regeneration to repair damage from ionizing radiation. Augmenting WNT signaling enhanced this regenerative process and prevented radiation- and chemotherapy-induced hair loss, highlighting a potential approach to manage alopecia during cancer treatment.
30 citations
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April 2013 in “Journal of Investigative Dermatology” This study found that ionizing radiation primarily affects keratinocyte stem cells in the hair follicle, suggesting they play a central role in radiation-induced hair graying, rather than melanocyte stem cells.
5 citations
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July 2022 in “Radiation Research” This study developed a mouse model to simulate chronic radiation-induced salivary dysfunction, revealing dose-dependent saliva reduction and glandular changes, which may help advance salivary regenerative therapies.
1 citations
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March 2024 in “International journal of molecular sciences” This review discusses how ionizing radiation causes skin damage by inducing cellular senescence in keratinocytes, which secrete inflammatory mediators, recruiting immune cells and exacerbating inflammation, impacting the skin barrier function and healing.
March 2026 in “International Journal of Molecular Sciences” In this laboratory study, researchers observed that mouse vascular endothelial cells exhibit dynamic changes after exposure to ionizing radiation, including a transient endothelial subpopulation that facilitates vascular-epidermal communication and skin repair, with shifting roles in angiogenesis and immune surveillance over time.
This study suggests that targeting the activation of transit-amplifying cell-derived progenitor cells may help prevent hair loss from chemotherapy and radiotherapy by promoting hair follicle regeneration.
April 2017 in “Journal of Investigative Dermatology” This study found that down-regulation of sonic hedgehog gene expression is a critical early event in chemotherapy-induced tissue damage in hair and feather follicles.
25 citations
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April 2018 in “Electromagnetic biology and medicine” This study found that radiofrequency radiation from mobile phone use may increase DNA damage in hair follicle cells of the ear canal, with greater exposure duration linked to higher damage levels.
This research reports that after genotoxic stress from ionizing radiation or chemotherapy, hair follicles can utilize progenitor cells from transit-amplifying compartments, not quiescent stem cells, for repair, suggesting a potential therapeutic approach to prevent therapy-induced hair loss by activating these progenitors.
In this study, various cellular responses and signaling pathways were examined in hair follicles after exposure to ionizing radiation, including the effects of Wnt3a treatment, with findings noted in apoptosis, DNA damage, and differentiation processes.
Results are not reported in this study, which investigated the effects of radiation on hair follicles and evaluated various cellular responses and signaling pathways, particularly focusing on WNT signaling and the impact of Wnt3a treatment.
69 citations
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January 1995 in “PubMed” This study suggests that the structure and function of mouse melanocytes in the epidermis and hair bulb are influenced by genetic factors and local tissue environment, including hormones and growth factors.
January 2023 in “Journal of Ravishankar University” This review discusses the role of oxidative stress and reactive oxygen species in the development of androgenic alopecia and reports no new clinical findings.
3 citations
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June 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This article discusses the clinical spectrum and pathobiology of radiotherapy-induced alopecia and reports no new research findings, highlighting potential pathways for future targeted RIA management.
2 citations
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October 2000 This report discusses a request for a health hazard evaluation at Equifax in St. Petersburg, Florida concerning potential workplace exposures related to reported employee health issues, particularly hair loss, but provides no new results.
February 2026 in “American Journal of Clinical Dermatology” This source discusses how radiotherapy-induced skin fibrosis, a chronic side effect affecting cancer survivors' quality of life, is driven by ongoing inflammation and fibroblast activity, and emphasizes the need for comprehensive dermatologic management and better diagnostic tools.
January 2024 in “GeroScience” This review explores how radiation-induced hair graying can be used as a model to study the mechanisms behind hair graying, focusing on cellular senescence and potential therapeutic targets to address age-related changes. Results are not provided.
January 1990 in “Springer eBooks” Some chemicals can permanently or temporarily remove color from skin and hair, which can be distressing and is not well-regulated in cosmetics.
May 1979 in “Archives of Dermatology” This review discusses the associations between nonscarring alopecia and conditions like vitiligo and autoimmune reactions, but reports no new clinical results.
37 citations
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April 2010 in “FEBS Letters” In this study, researchers reported that the activation of EDA2R by p53 leads to p53-dependent cell death in cancer cells and is involved in chemotherapy-induced hair loss.
19 citations
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December 2015 in “Journal of Investigative Dermatology” This study found that keratin 17 expression is initially down-regulated and later strongly up-regulated by ionizing radiation in a rat model, with p53 repressing early transcription.