Modeling of Ionizing Radiation Induced Hair Follicle Regenerative Dynamics

    September 2022 in “ Journal of Theoretical Biology ”
    Cecilia Duran, Manuel Barcenas, William R. Holmes
    Studysummary This study developed a mathematical model to explore hair follicle regeneration mechanisms, showing that low spontaneous apoptosis rates help regenerate hair follicles after ionizing radiation, while high rates lead to degeneration during the catagen phase.
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    Research cited in this study 22

    1. A Probabilistic Boolean Model on Hair Follicle Cell Fate Regulation by TGF-Beta Biophysical Journal · 2022
    2. The Global Regulatory Logic Of Organ Regeneration: Circuitry Lessons From Skin And Its Appendages Biological reviews/Biological reviews of the Cambridge Philosophical Society · 2021
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    6. Epidermal Growth Factor Promotes Proliferation and Migration of Follicular Outer Root Sheath Cells via Wnt/β-Catenin Signaling Cellular physiology and biochemistry · 2016
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    11. Bone Morphogenetic Proteins and Their Antagonists in Skin and Hair Follicle Biology Journal of Investigative Dermatology · 2003
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    13. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
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    15. Conditional Disruption of Hedgehog Signaling Pathway Defines Its Critical Role in Hair Development and Regeneration Journal of Investigative Dermatology · 2000
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    17. Induction of the Hair Growth Phase in Postnatal Mice by Localized Transient Expression of Sonic Hedgehog Journal of Clinical Investigation · 1999
    18. Analysis of Apoptotic Cell Death in Human Hair Follicles In Vivo and In Vitro Journal of Investigative Dermatology · 1998
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