Biomechanics of Hair Fiber Growth: A Multi-Scale Modeling Approach

    M. Shafayet Zamil, Duane P. Harland, Brian K. Fisher, Michael Davis, James R. Schwartz, Anja Geitmann
    TLDR The model shows that factors like follicle shape and stiffness are key for hair growth and anchoring.
    The study developed a multi-scale finite element analysis (FEA) modeling framework to understand the biomechanical forces and impedances involved in mammalian hair fiber growth. The overall follicle model was supported by tissue-scale and cell-scale models, which provided inputs and helped deconvolute biomechanical phenomena. The simulations suggested that factors such as follicle geometry, tissue hydrostatic state, material stiffness, keratinization-mediated hardening, and desmosome-correlated shear sliding behaviors play crucial roles in hair fiber protrusion. The model aimed to predict which structural features and forces are significant in hair growth, guiding future experimental studies.
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