The Walking Dead: Sequential Nuclear and Organelle Destruction During Hair Development

November 2017 in “ British Journal of Dermatology ”

Leigh Ann Jones, Duane P. Harland, Bradley B. Jarrold, John E. Connolly, Michael G. Davis

hair follicle keratin Bnip3L mitophagy reactive oxygen species nuclear DNA

Studysummary This study proposes a model describing the transformation process from living to dead cells during early hair formation, highlighting the stepwise degradation of cellular functions.

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Research cited in this study

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research Compartmentation of Mitochondrial and Oxidative Metabolism in Growing Hair Follicles: A Ring of Fire

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This study visualized mitochondrial metabolism in cultured bovine hair follicles and plucked human hairs, finding that ROS and mitochondrial polarization correlate in specific hair follicle regions, particularly near keratin deposition sites.

research Oxidative Damage Control in a Human Mini-Organ: Nrf2 Activation Protects Against Oxidative Stress-Induced Hair Growth Inhibition

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This study found that activating Nrf2 in human hair follicles significantly reduced oxidative stress, lipid peroxidation, and protected against hair growth inhibition, suggesting a protective role for Nrf2 against redox insult in this context.

research The Role of Oxidative Damage in Poor Scalp Health: Ramifications to Causality and Associated Hair Growth

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This study demonstrated that oxidative stress contributes to dandruff, and using a potentiated ZPT shampoo improves scalp and hair condition by reducing oxidative stress.

research The Impact of Oxidative Stress on Hair

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Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions

research Mitochondrial Function in Murine Skin Epithelium Is Crucial for Hair Follicle Morphogenesis and Epithelial-Mesenchymal Interactions

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research Age-Induced Hair Greying: The Multiple Effects of Oxidative Stress

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This review discusses the role of oxidative stress in hair greying and suggests that understanding melanocyte susceptibility at different follicular locations may help develop therapies for preventing and reversing the process; it reports no new experimental results.

research Cell Death by Cornification

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research Mitochondrial Reactive Oxygen Species Promote Epidermal Differentiation and Hair Follicle Development

277 citations , February 2013 in “Science Signaling”

This study found that mitochondrial reactive oxygen species are crucial for normal epidermal differentiation and hair follicle growth, as demonstrated by impaired development in mice lacking these signals due to a keratinocyte-specific TFAM deficiency.

research The Role of Disulfide Bond Formation in the Structural Transition Observed in the Intermediate Filaments of Developing Hair

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research Annotation of Sheep Keratin Intermediate Filament Genes and Their Patterns of Expression

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research Adamson's Fringe, Horatio George Adamson, and Kligman's Experiments and Observations on Tinea Capitis

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research The Cycling Hair Follicle as an Ideal Systems Biology Research Model

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This review summarizes fundamental concepts and recent advancements in hair follicle biology, including insights from mouse models into broader molecular and cellular processes relevant to regeneration and development.

research Oxidative Stress in Aging of Hair

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research Novel Type I Hair Keratins K39 And K40 Are The Last To Be Expressed In Differentiation Of The Hair: Completion Of The Human Hair Keratin Catalog

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research In Vivo Formation Steps of the Hard Alpha-Keratin Intermediate Filament Along a Hair Follicle: Evidence for Structural Polymorphism

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research Human Hair Keratin-Associated Proteins

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research Trichohyalin Mechanically Strengthens the Hair Follicle

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research The Cytology and Cytochemistry of the Wool Follicle

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This chapter reviews the complexity of hair and wool follicle formation, emphasizing the importance of cytological studies to understand the relationship between cellular components.

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research Acid Phosphatase Distribution in the Wool Follicle: Fate of Organelles in Keratinized Cells

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This study identified the presence of recognizable organelles, such as lysosomes and mitochondria, in both the keratinized fiber and the hardened inner root sheath of the Romney wool follicle.