The Walking Dead: Sequential Nuclear and Organelle Destruction During Hair Development

    November 2017 in “ British Journal of Dermatology ”
    Leigh Ann Jones, Duane P. Harland, Bradley B. Jarrold, John E. Connolly, Michael G. Davis
    TLDR Cells in hair die by breaking down their DNA and mitochondria as they form keratin.
    The study proposed a model for the transition of cells from living to dead during the initial 1 mm of hair formation. It suggested that nucleated cells first degrade their nuclear DNA while still performing essential functions, such as respiration and producing reactive oxygen species for keratin cross-linking. As keratin bundles accumulate, the expression of Bnip3L initiates mitophagy, eliminating the cells' last living characteristics and completing their transition to a dead state within the hair follicle.
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