TLDR Wool follicle cells are more complex than previously thought.
The study from 1982 reported on the early stages of fiber differentiation in wool follicles, highlighting the complexity of cell movement and incorporation into fibers. It identified new cellular features in the bulb and dermal papilla, such as mast cells, specialized basal lamina, hemidesmosomes, and primary cilia, which indicated a more intricate bulb-dermal papilla function than previously understood. These findings suggested a sophisticated system of cell supply and integration during wool fiber development.
90 citations
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January 1979 in “International review of cytology” Wool follicles are complex, involving interactions between different cell types and structures.
28 citations
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September 2013 in “Journal of Investigative Dermatology” The document concludes that dermal papilla cells are key for hair growth and could be used in new hair loss treatments.
314 citations
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April 2010 in “Developmental Cell” β-catenin in the dermal papilla is crucial for normal hair growth and repair.
28 citations
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March 2010 in “Histochemistry and cell biology” Skin cells can help create early hair-like structures in lab cultures.
6 citations
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January 1994 in “Skin Pharmacology and Physiology” The study explored the role of dermal papillae in hair growth using in vitro cultures. It was found that outer root sheath cells (ORSCs) grew more actively when cultured with dermal papillae, suggesting the presence of papilla-derived factors that stimulate ORSC growth. Additionally, epithelial cells from the bulb matrix grew towards implanted dermal papillae, indicating that dermal papillae might produce factors that attract these cells. When the dermal papilla remained attached to the hair bulb matrix, hair and follicle elongation continued for over a week. However, detachment or damage to the papilla-matrix junction suppressed hair and follicle growth, highlighting the importance of this attachment for normal development.
30 citations
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February 1977 in “Nature”
