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GlossaryDesmosomes

specialized cell structures that glue adjacent cells together

Desmosomes are specialized structures in the cell membrane that act like glue, holding cells together, particularly in tissues that experience a lot of stress, such as skin and heart muscle. They are composed of proteins that link the cytoskeletons of adjacent cells, providing mechanical strength and stability to tissues.

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research Imaging Nanoscale Changes in Desmosome Protein Organization

April 2018 in “Journal of Investigative Dermatology”

Desmoglein 3 organization in cell connections changes without calcium, affecting cell adhesion.

research Using the Frog Embryonic Epidermis as a Model to Study Desmosome Function During Development

August 2019 in “Journal of Investigative Dermatology”

Frog skin cells need the protein desmoplakin for proper development and cell layer formation.

research Ichthyosis Follicularis with Alopecia and Photophobia in a Mother and Daughter

36 citations, January 2000 in “British journal of dermatology/British journal of dermatology, Supplement”

A mother and daughter had severe skin, hair, and eye issues linked to IFAP.

research Histopathological and Ultrastructural Study of Ectodermal Dysplasia/Skin Fragility Syndrome

31 citations, August 2005 in “The American Journal of Dermatopathology”

The study concluded that PKP1 is essential for skin integrity and hair growth, and its dysfunction causes the symptoms of ectodermal dysplasia/skin fragility syndrome.

research Regulation of Hair Shedding by the Type 3 IP3 Receptor

19 citations, May 2012 in “The journal of investigative dermatology/Journal of investigative dermatology”

The type 3 IP3 receptor is important for controlling hair loss and growth.

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