Silencing the Androgen Receptor: New Skills for Antiandrogen Oligonucleotide Skin and Hair Therapy

    February 2009 in “ Journal of Dermatological Science ”
    Andrea Dugour, Karin Hagelin, Cintia Smus, María Eugenia Balañá, Néstor Kerner
    TLDR Targeting androgen receptors with antiandrogen oligonucleotides could effectively treat hair loss.
    The document discussed the role of androgens in regulating hair growth and their contribution to androgenetic alopecia, a condition affecting over 50% of men by age 50 and women over 60. It highlighted that androgens, particularly testosterone and dihydrotestosterone, inhibit hair follicle activity by shortening the anagen phase and inducing catagen, leading to follicle miniaturization and hair thinning. The study suggested that targeting androgen receptors with antiandrogen oligonucleotides could be a promising therapeutic approach, as current treatments were not fully effective and had potential side effects.
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      community Binding affinity of pyrilutamide!

      in Update  171 upvotes 3 years ago
      Pyrilutamide, a nonsteroidal antiandrogen drug under development for the potential treatment of androgenic alopecia. The conversation discusses its binding affinity to the androgen receptor and the timeline for possible availability after trials are completed in the United States and China.

      community New Approach to Ketoconazole or just waste of time?

      in Ketoconazole  21 upvotes 1 year ago
      The post discusses using 2% ketoconazole shampoo as a competitive androgen receptor antagonist for hair loss, applied for 1.5 hours daily. The user questions its effectiveness and potential benefits compared to finasteride and minoxidil.

      community A Technical Question About Pyrilutamide

      in Research/Science  5 upvotes 2 years ago
      Pyrilutamide is believed to be more effective than RU58841 and 1 mg finasteride in treating hair loss, with no systemic hormonal effects and the potential to block more than 31% of scalp DHT. It may also antagonize scalp testosterone due to its action as an androgen receptor antagonist.

      community Overwhelming amount of anti-androgens

      in Female 2 years ago
      The conversation discusses the effectiveness of anti-androgens for hair loss, with a preference for topical treatments like RU58841 over oral options due to better scalp concentration and fewer side effects. Topical finasteride at 0.1% may provide some results, especially when combined with a topical androgen receptor antagonist like RU58841.

      community Minoxidil is NOT an Anti-androgen. No.

      in Research/Science  43 upvotes 1 month ago
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