A Review of Hair Anatomy and Animal Models for Alopecia
October 2023
in “
Recent Trends in Pharmaceutical Sciences and Research
”
Anagen Catagen Telogen Exogen hormones genetics Alopecia Alopecia areata Androgenic alopecia Alopecia universalis Involutional alopecia Telogen effluvium Trichotillomania Scarring alopecia mice models rats models testosterone sensitivity Dihydrotestosterone DHT chemotherapy-induced alopecia transgenic animals C3H/HeJ mice models hair growth cycle hair loss genetic hair loss hormonal hair loss chemotherapy hair loss
TLDR The paper concludes that animal models help in understanding hair loss causes and developing new treatments.
The paper "A Review of Hair Anatomy and Animal Models for Alopecia" discusses the complex process of the hair growth cycle, which includes four distinct phases: Anagen, Catagen, Telogen, and Exogen, regulated by factors like hormones and genetics. Imbalances in this cycle can lead to hair loss or Alopecia, caused by various factors such as genetics, hormonal imbalances, medication, poor diet, smoking, and environmental factors. Alopecia is classified into several types including Alopecia areata, Androgenic alopecia, Alopecia universalis, Involutional alopecia, Telogen effluvium, Trichotillomania, and Scarring alopecia. The paper also discusses the use of animal models, specifically mice and rats, to study the pathophysiology of Alopecia. These models are used to study different types of Alopecia, such as androgenic Alopecia, which occurs due to testosterone sensitivity or the Dihydrotestosterone (DHT) hormone, chemotherapy-induced alopecia, and alopecia areata, using transgenic animals and C3H/HeJ mice models. These models can aid in developing new treatment approaches for Alopecia.
