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research The Optimal Indication for Testosterone Replacement Therapy in Late Onset Hypogonadism

17 citations , February 2019 in “Journal of Clinical Medicine”

This article reviews guidelines for testosterone replacement therapy in late-onset hypogonadism, emphasizing the need for clear indications and appropriate testing before treatment, but provides no new research findings.

research Tissue insulin sensitivity and body weight in polycystic ovary syndrome

39 citations , August 2001 in “Clinical endocrinology”

This study found that lean women with PCOS have a similar degree of tissue insulin resistance as obese women with PCOS, suggesting that insulin resistance may be a primary feature of the syndrome.

A Systematic Review of the Potential Role of Cinnamomum Species in Modulating Insulin Sensitivity and Hyperandrogenism in Polycystic Ovary Syndrome

research A Systematic Review of the Potential Role of Cinnamomum spp. in Modulating Insulin Sensitivity and Hyperandrogenism in Polycystic Ovary Syndrome (PCOS)

February 2026 in “World Journal of Interdisciplinary Innovation Sciences”

This systematic review found that cinnamon supplementation may modestly improve insulin sensitivity and potentially reduce hyperandrogenism in women with PCOS, but stresses the need for large-scale clinical trials.

research No Evidence that 2D:4D is Related to the Number of CAG Repeats in the Androgen Receptor Gene

40 citations , January 2013 in “Frontiers in Endocrinology”

Finger length ratios are not linked to the number of specific gene repeats affecting testosterone sensitivity.

research A Review of Hair Anatomy and Animal Models for Alopecia

October 2023 in “Recent Trends in Pharmaceutical Sciences and Research”

This review examines the anatomy and physiology of hair, focusing on the hair growth cycle and various types of alopecia, using animal models such as mice and rats to study the condition's pathophysiology and aid in developing new treatments.

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community How does testosterone and dht work?

14 upvotes 4 weeks ago

Hair loss is influenced by follicle sensitivity to DHT, which increases with age, rather than just testosterone levels. Treatments like finasteride and hair transplants are used to manage hair loss, with transplants needing medication to protect surrounding sensitive hair.

community Ray Peat: Testosterone Isn’t the Culprit, Prolactin and Cortisol Drive Hair Loss (2016)

in Research/Science 110 upvotes 10 months ago

Prolactin and cortisol are identified as key factors in hair loss, with stress hormones impacting hair shedding. Finasteride and minoxidil are effective treatments, while DHT's role and individual sensitivity are significant factors.

community Low testosterone and dht. What should I do?

in Finasteride/Dutasteride 7 upvotes 2 years ago

The user has low testosterone and DHT levels and is considering taking finasteride for Norwood 2 hair loss with diffuse thinning. They are seeking advice on whether low DHT indicates high sensitivity to DHT in the scalp and opinions on their lab values.

community Very high testosterone and estradiol on finasterid 1 mg. Am I cooked?

3 upvotes 9 months ago

A 29-year-old male on 1 mg Finasteride for 3 months has experienced a significant increase in testosterone and estradiol levels, with no major side effects except slightly oilier skin and increased emotional sensitivity. The user is concerned about these hormonal changes and seeks advice, as their general practitioner is not knowledgeable about the issue.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

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Learn

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learn Cyproterone

a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

learn Bicalutamide

a nonsteroidal anti-androgen, most commonly used orally for women

Could bicalutamide help trans women regrow hair lost to testosterone? No study has tested bicalutamide for hair regrowth in trans women. In cisgender women the only randomized trial found it added nothing to minoxidil, and it is an off-label prescription drug that requires liver monitoring.

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