Cutaneous Immunopathology of Androgenetic Alopecia

    August 1991 in “ The Journal of the American Osteopathic Association ”
    James B. Young, Eugene T. Conte, Matt L. Leavitt, Mary Ann Nafz, Arnold L. Schroeter
    TLDR Inflammation may play a role in causing androgenetic alopecia.
    The study from 1991 examined the role of inflammation in androgenetic alopecia (AGA) by analyzing scalp biopsy specimens from 26 patients with AGA and comparing them to controls. It found that 96% of the AGA patients had granular deposits of Immunoglobulin M or C3 at the basement membrane, compared to 12% of controls, and 31% had C3 deposits on eccrine myoepithelial cells, while none of the controls did. Porphyrins were present in the pilosebaceous canal of 58% of AGA patients versus 12% of controls. These findings suggested that inflammation, potentially exacerbated by factors like Propionibacterium acnes and light exposure, might contribute to the development of AGA, alongside hormonal and genetic factors.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community The MPB itch aka DHT itch is very real.

      in Chat  9 upvotes 2 years ago
      Hair loss itch is caused by DHT attacking follicles and stimulating nerves. Finasteride users who respond well don't experience this itch.

      community FINASTRIDE and switch to DUTASTRIDE, my experience

      in Progress Pictures  145 upvotes 1 year ago
      The user shared their experience with Finasteride and Dutasteride for hair loss. They initially had success with Finasteride but switched to Dutasteride after experiencing shedding, which continued, and are now considering a hair transplant.

      community My scalp punch biopsy results🤔?

      in Female  8 upvotes 2 years ago
      Female using Rogaine foam for hair loss had scalp punch biopsy, diagnosed with Androgenetic Alopecia (AGA). Doctor recommended starting Spironolactone 50mg.

    Similar Research

    5 / 1000+ results