TLDR Accurate protein modeling can help develop new treatments for prostate cancer and other diseases.
The document reviewed the homology modeling of 5-alpha-reductase 2, emphasizing its role in steroid metabolism and human diseases. It highlighted the significance of accurate protein modeling for drug discovery, particularly in developing inhibitors for therapeutic purposes. The study underscored the potential of computational tools like virtual screening and molecular docking in identifying effective inhibitors, which could help design new treatments for conditions such as prostate cancer and benign prostatic hyperplasia.
Cited in this study
4 / 4 results
13 citations
,
June 2017 in “Biochimie open” All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.
24 citations
,
June 2013 in “Expert opinion on pharmacotherapy” Dutasteride effectively treats benign prostatic hyperplasia but isn't approved for preventing prostate cancer.
218 citations
,
January 2012 in “Advances in Urology” The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.
10 citations
,
June 2010 in “Expert Opinion on Drug Metabolism & Toxicology” Finasteride reduces prostate cancer risk but may increase high-grade cancer chances.
1 citations
,
June 2021 in “Singapore Medical Journal” 
4 citations
,
January 2015 in “Journal of drug assessment” Finasteride gel effectively and safely reduces hair thickness in women with excessive hair growth.
27 citations
,
July 2009 in “Experimental and Clinical Endocrinology & Diabetes” Finasteride safely reduces excessive hair growth in women.
29 citations
,
June 2004 in “Annals of Pharmacotherapy” Finasteride reduces hirsutism effectively with fewer side effects but is a second-choice treatment due to safety concerns.
40 citations
,
February 2003 in “Gynecological Endocrinology” Finasteride effectively reduces hair growth in women with polycystic ovary syndrome or idiopathic hirsutism.
27 citations
,
November 1998 in “Journal of Endocrinological Investigation” Finasteride significantly reduces hair growth in women with idiopathic hirsutism.
10 citations
,
December 1995 in “Journal of women's health” Finasteride reduces hair growth in women with hirsutism and works better with electrolysis.
