TLDR Finasteride reduces prostate cancer risk but may increase high-grade cancer chances.
The document discusses the use of finasteride as a chemopreventive agent for prostate cancer. The Prostate Cancer Prevention Trial showed that finasteride can reduce the risk of developing prostate cancer. However, there is a discussion on the higher incidence of high-grade cancer in the finasteride arm. The document also mentions other chemopreventive agents for prostate cancer. Prostate cancer is the most common non-cutaneous malignancy in males in the US, and chemotherapeutic prevention studies are an attractive option given the high incidence of the disease, hormonal influences, and long latency period.
235 citations
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September 2004 in “The Journal of urology/The journal of urology” Drugs that block DHT production can effectively treat enlarged prostate and improve urinary issues with some sexual side effects.
1054 citations
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February 1998 in “The New England Journal of Medicine” Finasteride reduces urinary issues and surgery need in men with enlarged prostates by over 50%.
211 citations
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November 1990 in “The Journal of Steroid Biochemistry and Molecular Biology” Finasteride effectively treats BPH, but needs more trials to understand potential.
147 citations
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April 1990 in “The Journal of Clinical Endocrinology and Metabolism” Finasteride safely lowers DHT levels without affecting testosterone.
August 2024 in “International Journal of Basic & Clinical Pharmacology” Secretome-based therapies could improve hair growth better than current treatments.
55 citations
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July 2013 in “Dermatologic therapy” Some dermatological medications can impair male fertility, so consult a doctor before trying to conceive.
1113 citations
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August 1999 in “The New England Journal of Medicine” Hair follicle biology advancements may lead to better hair growth disorder treatments.
32 citations
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January 2018 in “American Journal of Clinical Dermatology” Hormone therapy affects hair growth in transgender individuals, with testosterone potentially causing hair loss in trans men and estrogen reducing facial/body hair in trans women; treatment options vary.
18 citations
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March 2008 in “British Journal of Dermatology” Finasteride works better for hair loss in patients 26 or younger.
