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Glossary Inhibitors

substances that slow or prevent specific biological processes

Inhibitors are substances that slow down or prevent specific chemical reactions or biological processes. In the context of hair and alopecia, inhibitors can target enzymes or pathways that contribute to hair loss, potentially offering therapeutic benefits by halting or reversing the condition.

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Research

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research Inhibitors of 5α-Reductase in the Treatment of Benign Prostatic Hyperplasia

52 citations , February 2006 in “Current pharmaceutical design”

This review discusses the use of 5α-reductase inhibitors in treating benign prostatic hyperplasia, highlighting their long-term effectiveness and benefits when combined with α1-adrenergic antagonists; it reports no new clinical results.

research Inhibitors of 5α -Reductase Type I in LNCaP Cells from the Roots of Angelica koreana

22 citations , February 2002 in “Planta Medica”

In this study, osthenol was identified as a highly potent inhibitor of 5alpha-reductase type I in LNCaP cells, significantly outperforming finasteride.

research Inhibidores de JAK: usos en dermatología. Parte 1: generalidades, aplicaciones en vitíligo y en alopecia areata

20 citations , December 2020 in “Actas Dermo-Sifiliográficas”

This review examines the JAK/STAT signaling pathway's significance in inflammatory skin diseases and evaluates the efficacy and safety of oral and topical JAK inhibitors for treating vitiligo and alopecia areata. Results are not reported in this study.

research Inhibitors of 5α-reductase-related side effects in patients seeking medical care for sexual dysfunction.

13 citations , November 2012 in “PubMed”

This study found that in men with sexual dysfunction, use of 5ARI may reduce sexual drive and spontaneous erections without worsening pre-existing erectile or ejaculatory issues.

research Activity of steroid 4 and derivatives 4a–4f as inhibitors of the enzyme 5α-reductase 1

3 citations , June 2018 in “Bioorganic & medicinal chemistry”

This study identified that derivatives 4, 4b, and 4c strongly inhibited the enzyme type 1 5α-reductase and decreased reproductive organ weights in hamsters, suggesting potential as prodrugs for prostate tumor growth inhibition.

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Community Join

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community Turmeric Inhibits Conversion of Testosterone to DHT; Creatine Enhances It - Kyle Gillett

56 upvotes 4 years ago

Turmeric may slightly inhibit DHT, but it likely doesn't significantly impact hair loss. Creatine might increase DHT levels, but its effect on hair loss is debated and not conclusively proven.

community Aromatise inhibitor for finasteride-estrogen side effects?

5 upvotes 4 years ago

A user experienced mild side effects from 0.5mg finasteride daily, including increased estradiol and minor gynecomastia. They are considering taking a low dose of exemestane to reduce estrogen levels.

community The ending of alopecia? Corticosterone inhibits GAS6 to govern hair follicle stem-cell quiescence

63 upvotes 4 years ago

Corticosterone inhibits GAS6, affecting hair follicle stem-cell activity, with potential implications for stress-related hair loss. Ashwagandha and Vitamin K are suggested for reducing cortisol, but their effectiveness is debated.

community Minoxidil inhibits lysyl hydroxylase which is needed to produce collagen. If I take 2,5...5 mg of minoxidil every day can I cause my skin to age prematurely?

32 upvotes 1 year ago

Oral minoxidil is effective for hair loss and unlikely to significantly affect collagen synthesis, making it a safe option without causing premature skin aging. Users report positive hair regrowth without noticeable skin aging.

community When will FAK Inhibitors / Standford Hydrogel be on the market for hair transplants?

9 upvotes 8 months ago

The conversation discusses the delay in bringing FAK inhibitors and Stanford's hydrogel to market for hair transplants, with a preference for FAK inhibitors over Verteporfin due to their superior potential in preventing scarring. The user expresses frustration over the slow progress and hopes for faster development by companies like FAKnostics.

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Learn

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learn Baricitinib

JAK inhibitor that reduces inflammation and immune attacks on hair follicles, leading to potential hair regrowth, especially in alopecia areata cases

learn Tofacitinib

a JAK inhibitor for alopecia areata and other autoimmune conditions

learn PP405

mitochondrial pyruvate carrier (MPC) inhibitor by Pelage in early trials

learn Follistatin

glycoprotein that inhibits TGF-β and promotes hair growth by antagonizing activin

learn Clascoterone

a novel topical treatment that inhibits DHT on androgen receptors

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