Testosterone Therapy in Women: A Literature Review of Clinical Indications, Dosing, Routes of Administration, and Safety

    April 2026 in “ Cureus ”
    Juana Montero Bernaldez, Elizabeth R Burgess, Rebeca Martinez, Manuel Peñalver
    Studysummary This narrative review concludes that long-term randomized controlled trials are needed to establish clear guidelines for testosterone therapy in women, given the lack of FDA-approved formulations and the variable quality of current treatments.
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    Research cited in this study 8

    1. Cardiovascular Safety and Benefits of Testosterone Implant Therapy in Postmenopausal Women: Where Are We? Pharmaceuticals · 2023
    2. Testosterone in Women: Measurement and Therapeutic Use Journal of obstetrics and gynaecology Canada · 2017
    3. Androgens and Female Sexual Function and Dysfunction—Findings From the Fourth International Consultation of Sexual Medicine The Journal of Sexual Medicine · 2016
    4. Androgen Therapy in Women: A Reappraisal: An Endocrine Society Clinical Practice Guideline The Journal of Clinical Endocrinology & Metabolism · 2014
    5. Testosterone Implants in Women: Pharmacological Dosing for a Physiologic Effect Maturitas · 2012
    6. Improvement in Scalp Hair Growth in Androgen-Deficient Women Treated with Testosterone: A Questionnaire Study British Journal of Dermatology · 2011
    7. Safety of Testosterone Treatment in Postmenopausal Women Fertility and Sterility · 2007
    8. Endocrine and Intracrine Sources of Androgens in Women: Inhibition of Breast Cancer and Other Roles of Androgens and Their Precursor Dehydroepiandrosterone Endocrine Reviews · 2003