Testosterone Pellets in Women: Revisiting Safety and Clinical Outcomes

The review discusses the use of subcutaneous testosterone pellets in women, particularly for hypoactive sexual desire disorder (HSDD), highlighting both potential benefits and significant safety concerns. While some studies suggest improvements in sexual function and psychological well-being, the evidence is primarily observational and lacks the rigor of randomized controlled trials (RCTs). The therapy's supraphysiologic testosterone peaks raise safety issues, including androgenic effects and metabolic changes. The review emphasizes the need for cautious interpretation of current findings, structured monitoring, and more robust RCTs to confirm safety and efficacy, especially given the lack of regulatory approval and potential biases in existing studies.