Anabolic and Metabolic Effects of Testosterone and Other Androgens: Direct Effects and Role of Testosterone Metabolic Products

    January 2017 in “ Endocrinology ”
    Jonas Čeponis, Christina Wang, Ronald S. Swerdloff, Yang Liu
    TLDR Testosterone and its metabolites have varied effects on different body systems, especially during puberty.
    The document reviewed the anabolic and metabolic effects of testosterone and other androgens, focusing on their direct effects and the role of testosterone metabolic products. It highlighted various studies demonstrating that testosterone and its derivatives significantly influenced bone mineral density, erythropoiesis, and body composition in men. For instance, testosterone supplementation increased bone mineral density in older men with low serum testosterone, and it also suppressed hepcidin, potentially leading to increased red blood cell production. Additionally, the document discussed the differential effects of androgens and estrogens on bone turnover and the implications of androgen deprivation therapy on metabolic health, such as increased risks of diabetes and cardiovascular disease.
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