Anabolic and Metabolic Effects of Testosterone and Other Androgens: Direct Effects and Role of Testosterone Metabolic Products

January 2017 in “ Endocrinology ”

Jonas Čeponis, Christina Wang, Ronald S. Swerdloff, Yang Liu

testosterone androgens testosterone metabolic products bone mineral density erythropoiesis body composition testosterone supplementation hepcidin red blood cell production androgen deprivation therapy metabolic health diabetes cardiovascular disease bone density red blood cells testosterone therapy heart disease

TLDR Testosterone and its metabolites have varied effects on different body systems, especially during puberty.

The document reviewed the anabolic and metabolic effects of testosterone and other androgens, focusing on their direct effects and the role of testosterone metabolic products. It highlighted various studies demonstrating that testosterone and its derivatives significantly influenced bone mineral density, erythropoiesis, and body composition in men. For instance, testosterone supplementation increased bone mineral density in older men with low serum testosterone, and it also suppressed hepcidin, potentially leading to increased red blood cell production. Additionally, the document discussed the differential effects of androgens and estrogens on bone turnover and the implications of androgen deprivation therapy on metabolic health, such as increased risks of diabetes and cardiovascular disease.

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Anabolic and Metabolic Effects of Testosterone and Other Androgens: Direct Effects and Role of Testosterone Metabolic Products

Research cited in this study

research Testosterone Alters Iron Metabolism and Stimulates Red Blood Cell Production Independently of Dihydrotestosterone

research Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men With Suppressed Testosterone Production

research Exogenous Testosterone Alone or with Finasteride Increases Physical Performance, Grip Strength, and Lean Body Mass in Older Men with Low Serum Testosterone

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