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research A New Look at the 5?-Reductase Inhibitor Finasteride

137 citations , March 2006 in “Cns Drug Reviews”

This review explores finasteride's effects on neuroactive steroid levels and their potential influence on disorders like depression and alcohol withdrawal but reports no new clinical findings.

research Prenatal and adult androgen activities in alcohol dependence

63 citations , April 2017 in “Acta psychiatrica Scandinavica”

This study observed that higher prenatal androgen loads were associated with more severe alcohol dependence in male patients and linked to behaviors of pregnant women that may influence their children’s androgen exposure.

research Social isolation‐induced increase in α₄and δ subunit gene expression is associated with a greater efficacy of ethanol on steroidogenesis and GABA_Areceptor function

60 citations , May 2006 in “Journal of Neurochemistry”

This study found that social isolation in rats enhanced ethanol's effects on brain steroidogenesis and GABA A receptor function, altering related behavior more than in non-isolated rats.

research Factors Related to Hair Antiretroviral Concentration: A Systematic Review of Global Literature

5 citations , March 2020 in “Aids Reviews”

This review found that hair antiretroviral concentration may be associated with several factors, including hair type and genetic factors, but not with race/ethnicity or alcohol use.

research Early post-natal neuroactive steroid manipulation modulates ondansetron effects on initial periods of alcohol consumption in rats

2 citations , June 2018 in “Physiology & behavior”

The study found that ondansetron decreased alcohol consumption only in adult rats that experienced altered neuroactive steroid levels from early post-natal finasteride exposure, suggesting increased 5HT3 receptor sensitivity in these rats.

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community Efficacy and Tolerability of N-Acetyl-Cysteine for Treatment of The Early-onset Androgenetic Alopecia in Men

26 upvotes 4 years ago

N-Acetyl-Cysteine (NAC) was found to improve hair parameters in men with early-onset androgenetic alopecia, showing increased terminal hair count and decreased vellus hair count, with good tolerability. NAC, used alone or with minoxidil, may help due to its antioxidant properties, though its effectiveness can vary among individuals.

community Mystery hair loss and colour change

5 upvotes 6 years ago

The user is experiencing severe hair loss and color change despite low testosterone levels and healthy lifestyle changes. They have tried ketoconazole shampoo and consulted a dermatologist, who found no scalp issues but suggested using Toppik for coverage.

community Everyone is ignoring that plasma finasteride levels are 100x lower with topical compared to oral.

in Research/Science 140 upvotes 2 years ago

Topical finasteride results in plasma levels 100 times lower than oral finasteride, potentially reducing systemic side effects. Users report similar efficacy with fewer side effects, suggesting a preference for topical application.

community Why isnt topical fin talked about more?

in Chat 44 upvotes 1 year ago

Topical finasteride is less popular due to inconvenience, cost, and availability, while oral finasteride is favored for ease and safety. Some users experience side effects with topical use, but find it effective with minoxidil, though opinions on its efficacy vary.

community Does finasteride/dutasteride reverse aging?

in Chat 45 upvotes 1 year ago

Finasteride and dutasteride can improve skin texture and reduce acne by lowering DHT but do not reverse aging. They may enhance skin and hair health for some, but can also cause side effects like dry skin and sexual dysfunction.

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