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GlossaryNeurosteroids (neuroactive steroids)

steroids produced in the brain that affect neuron function

Neurosteroids, also known as neuroactive steroids, are a class of steroids synthesized in the brain and nervous system. They play a crucial role in modulating neuronal activity, influencing mood, stress response, and cognitive functions by interacting with neurotransmitter receptors such as GABA and NMDA.

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Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology

research Neuroactive Steroid Levels Are Modified in Cerebrospinal Fluid and Plasma of Post-Finasteride Patients Showing Persistent Sexual Side Effects and Anxious/Depressive Symptomatology

73 citations, July 2013 in “The Journal of Sexual Medicine”

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

research Neuroactive Steroid Levels and Psychiatric and Andrological Features in Post-Finasteride Patients

58 citations, April 2017 in “The Journal of Steroid Biochemistry and Molecular Biology”

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

research Effects of Subchronic Finasteride Treatment and Withdrawal on Neuroactive Steroid Levels and Their Receptors in the Male Rat Brain

33 citations, December 2015 in “Neuroendocrinology”

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

research Exploring the Impact of the Microbiome on Neuroactive Steroid Levels in Germ-Free Animals

11 citations, November 2021 in “International journal of molecular sciences”

Gut microbes significantly affect brain steroid levels.

research Effects of Neonatal and Adolescent Neuroactive Steroid Manipulation on Locomotor Activity Induced by Ethanol in Male Wistar Rats

7 citations, May 2017 in “Behavioural brain research”

Changing neuroactive steroid levels early in life can affect how adult rats respond to alcohol's stimulating effects.

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community Doctor says i shouldn't take fin because its "hormonal"

in Finasteride/Dutasteride 105 upvotes 11 months ago

A user in Turkey was advised by a dermatologist to avoid finasteride due to its hormonal effects and was prescribed minoxidil, shampoo, and vitamins instead. The user is considering seeking another doctor's opinion or buying finasteride directly from a pharmacy.

community Transient and Permanent Effects of Finasteride Use

in Research/Science 154 upvotes 3 years ago

Potential side effects of 5AR inhibitors like finasteride and dutasteride. Users debate risks, benefits, and personal experiences with these hair loss treatments.

community risks with finasteride and dutasteride

in Research/Science 139 upvotes 1 week ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

community Why is Kevin Mann (Haircafe) Hated?

in Chat 62 upvotes 2 years ago

Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

community What is the real impact of dutasteride on neurosteroids? A little review of 2 scientific datas

in Research/Science 21 upvotes 1 year ago

Dutasteride at 0.5 mg/day does not significantly alter allopregnanolone levels, but higher doses (2.5 mg/day) do. Dutasteride may also have anti-neuroinflammatory effects, but the impact on neurosteroids is still debated.

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