73 citations,
July 2013 in “The Journal of Sexual Medicine” Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.
58 citations,
April 2017 in “The Journal of Steroid Biochemistry and Molecular Biology” Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.
33 citations,
December 2015 in “Neuroendocrinology” Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.
11 citations,
November 2021 in “International journal of molecular sciences” Gut microbes significantly affect brain steroid levels.
September 2023 in “The Journal of Steroid Biochemistry and Molecular Biology” Stopping finasteride for male pattern hair loss changes neuroactive steroid levels in the brain and blood.
7 citations,
May 2017 in “Behavioural brain research” Changing neuroactive steroid levels early in life can affect how adult rats respond to alcohol's stimulating effects.
34 citations,
April 2014 in “Psychopharmacology” Stress and alcohol affect brain chemicals differently in rats, mice, and humans, influenced by genetic differences.
35 citations,
November 2019 in “Frontiers in Neuroendocrinology” Men and women have different levels and production of brain steroids, which may affect their risk for certain brain disorders.
31 citations,
March 2015 in “The Journal of Steroid Biochemistry and Molecular Biology” Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.
24 citations,
June 2013 in “Journal of neuroendocrinology” Neuroactive steroids and the enzyme 5α-reductase might be involved in the development of Tourette's syndrome.
1 citations,
January 2019 in “Elsevier eBooks” Neuroactive steroids may affect the risk and treatment of alcohol use disorders.
142 citations,
January 2019 in “Frontiers in Neuroendocrinology” Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.
137 citations,
March 2006 in “Cns Drug Reviews” Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.
37 citations,
September 2018 in “Psychoneuroendocrinology” Finasteride treatment in male rats causes long-lasting effects on depression-like behavior, brain cell growth, inflammation, and gut bacteria composition.
9 citations,
January 2018 in “American Journal of Men's Health” Finasteride use can cause lasting negative effects like sexual dysfunction, depression, anxiety, and cognitive issues.
8 citations,
April 2021 in “Journal of Clinical Investigation” Finasteride reduces opioid use and withdrawal symptoms in animals.
27 citations,
January 2017 in “Neuropsychopharmacology” The enzyme 5α-reductase is key in causing psychotic-like effects from sleep deprivation.
61 citations,
April 2014 in “The Journal of Steroid Biochemistry and Molecular Biology” Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.
123 citations,
December 2015 in “Journal of Neuroendocrinology” New targets for making and using brain-synthesized steroids could lead to better treatments for brain disorders and alcoholism.
40 citations,
December 2019 in “Neurobiology of Stress” Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.
18 citations,
March 2020 in “Frontiers in Neuroendocrinology” The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.
24 citations,
May 2015 in “Schizophrenia Research” A drug improved schizophrenia-like symptoms in stressed rats by changing brain steroid levels.
8 citations,
March 2020 in “Metabolites” Finasteride treatment changes urine metabolomics and steroid signatures, potentially monitoring effectiveness but may cause sexual side effects.
1 citations,
September 2017 in “Frontiers in Laboratory Medicine” Gut flora changes could potentially indicate depression, but more research is needed.
16 citations,
October 2017 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” Dutasteride may protect the brain in early Parkinson's disease.
March 2024 in “Journal of Endocrinological Investigation” Finasteride treatment in rats changed the expression of genes related to psychiatric and neurological functions, and these changes persisted after stopping the drug.
61 citations,
April 2018 in “Frontiers in endocrinology” Sex steroids produced in the hippocampus are crucial for brain functions like memory and learning in rodents.
2 citations,
December 2019 in “Neurobiology of Stress” Changing allopregnanolone levels in baby rats affects their adult behavior and alcohol use.
72 citations,
January 2011 in “Current Pharmaceutical Design” S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.
59 citations,
November 2018 in “Psychoneuroendocrinology” Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.