Effects of Neonatal and Adolescent Neuroactive Steroid Manipulation on Locomotor Activity Induced by Ethanol in Male Wistar Rats

    May 2017 in “ Behavioural brain research ”
    Iris Bartolomé, Anna Llidó, Sònia Darbra, Marc Pallarès
    Studysummary This study found that manipulating neuroactive steroids during early development stages in male rats influences alcohol-induced locomotor sensitivity, suggesting their role in addiction vulnerability.
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    Research cited in this study 10

    1. Neonatal Finasteride Administration Decreases Dopamine Release in Nucleus Accumbens After Alcohol and Food Presentation in Adult Male Rats Behavioural Brain Research · 2016
    2. Null Mutation of 5α-Reductase Type I Gene Alters Ethanol Consumption Patterns in a Sex-Dependent Manner Behavior Genetics · 2014
    3. Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats The International Journal of Neuropsychopharmacology · 2013
    4. Neonatal Neurosteroid Levels Are Determinant in Shaping Adult Prepulse Inhibition Response to Hippocampal Allopregnanolone in Rats Psychoneuroendocrinology · 2013
    5. Local Changes in Neurosteroid Levels in the Substantia Nigra Reticulata and the Ventral Tegmental Area Alter Chronic Ethanol Withdrawal Severity in Male Withdrawal Seizure-Prone Mice Alcoholism Clinical and Experimental Research · 2012
    6. Alteration of Neonatal Allopregnanolone Levels Affects Exploration, Anxiety, Aversive Learning, and Adult Behavioral Response to Intrahippocampal Neurosteroids Behavioural Brain Research · 2012
    7. Alterations in Neonatal Neurosteroids Affect Exploration During Adolescence and Prepulse Inhibition in Adulthood Psychoneuroendocrinology · 2009
    8. The Neurosteroid Environment in the Hippocampus Exerts Bi-Directional Effects on Seizure Susceptibility in Mice Brain Research · 2008
    9. Ethanol Intake Patterns in Female Mice: Influence of Allopregnanolone and the Inhibition of Its Synthesis Drug and Alcohol Dependence · 2008
    10. Studies on Neurosteroids XXV: Influence of a 5α-Reductase Inhibitor, Finasteride, on Rat Brain Neurosteroid Levels and Metabolism Biological & Pharmaceutical Bulletin · 2008

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