Neonatal Finasteride Administration Decreases Dopamine Release in Nucleus Accumbens After Alcohol and Food Presentation in Adult Male Rats

    August 2016 in “ Behavioural Brain Research ”
    Anna Llidó, Iris Bartolomé, Sònia Darbra, Marc Pallarès
    Image of study
    TLDR Finasteride given to baby rats reduces dopamine release and increases alcohol consumption in adult males.
    Neonatal administration of finasteride, a drug used to treat hair loss, was found to increase alcohol consumption in adult male rats. The study showed that rats with neonatal finasteride administration had an increased adult ethanol consumption for several days of the alcohol consumption phase, and a decreased dopamine release in the nucleus accumbens in response to both ethanol and food. These findings suggest that neonatal neurosteroid alterations can affect alcohol rewarding properties and may have implications for the use of finasteride in humans, particularly in relation to substance abuse and addiction.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results
      [object Object]

      community Efficacy of finasteride

      in Finasteride  10 upvotes 3 days ago
      The conversation discusses concerns about the effectiveness of finasteride for hair loss. The user is worried about being a non-responder to the treatment.

      community Topical fin formulation question

      in Finasteride  91 upvotes 1 month ago
      A user is making a homemade topical finasteride solution by dissolving crushed finasteride tablets in ethanol and PG. They are unsure if the final solution maintains the intended concentration after filtering and are considering adding more ethanol to ensure accuracy.

      community Topical finasteride carrier/vehicle

      in Finasteride  135 upvotes 2 months ago
      The user is considering making a homemade topical finasteride solution using an ethanol-based carrier. They are inquiring if a solution containing partially denatured ethyl alcohol and benzalkonium chloride is suitable.

      community Chest discomfort on finasteride?

      in Finasteride  72 upvotes 4 months ago
      A user experienced chest discomfort after taking finasteride for hair loss and is concerned about whether it is a side effect or an allergy. They are advised to consult a doctor and consider other hair loss treatments if necessary.

    Similar Research

    5 / 1000+ results