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Neonatal Finasteride Administration Alters Hippocampal α4 and δ GABAAR Subunits Expression and Behavioral Responses to Progesterone in Adult Rats

research Neonatal finasteride administration alters hippocampal α4 and δ GABAAR subunits expression and behavioural responses to progesterone in adult rats

17 citations , September 2013 in “The International Journal of Neuropsychopharmacology”

This study found that neonatal finasteride treatment in male rats altered hippocampal GABAA receptor subunit expression and led to increased anxiety-like behavior in response to progesterone in adulthood.

Neonatal Finasteride Administration Decreases Dopamine Release in Nucleus Accumbens After Alcohol and Food Presentation in Adult Male Rats

research Neonatal finasteride administration decreases dopamine release in nucleus accumbens after alcohol and food presentation in adult male rats

3 citations , May 2016 in “Behavioural Brain Research”

This study suggests that altering levels of the neurosteroid allopregnanolone during neonatal stages in rats may impact alcohol consumption and dopamine release in adulthood, indicating potential effects on alcohol reward properties.

research Neonatal finasteride induces anxiogenic-like profile and deteriorates passive avoidance in adulthood after intrahippocampal neurosteroid administration

27 citations , May 2008 in “Neuroscience”

This study found that altering neonatal neurosteroid levels affected anxiety and aversive learning in adult rats, possibly through changes in hippocampal GABAergic functions.

Neonatal Allopregnanolone or Finasteride Administration Modifies Hippocampal K+ Cl− Co-Transporter Expression During Early Development in Male Rats

research Neonatal allopregnanolone or finasteride administration modifies hippocampal K+ Cl− co-transporter expression during early development in male rats

10 citations , May 2014 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that altering neurosteroid levels during early development in male rats can influence KCC2 levels, underscoring the role of neurosteroids in hippocampal maturation.

research [P2.42]: Neonatal finasteride administration disrupts prepulse inhibition in adulthood

November 2010 in “International Journal of Developmental Neuroscience”

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community Finasteride is a risk in pregnancy with unprotected sex

118 upvotes 6 years ago

Finasteride may pose a risk during pregnancy, so using a condom is recommended if a partner is pregnant. It is advised to stop finasteride before trying to conceive due to potential effects on fetal development.

community Doctor won’t put me on fin or dut until my wife gives birth. Is this normal?

10 upvotes 2 years ago

A doctor advised against using finasteride or dutasteride during pregnancy. The user continues with oral and topical minoxidil, microneedling, tretinoin, Nizoral, and pyrilutamide.

community My Theory Of Androgenic Alopecia

16 upvotes 9 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Conceived on low dose topical fin (.025%), anyone else?

8 upvotes 6 months ago

A user expressed concern about using low-dose topical finasteride while conceiving, but was reassured that the risk of affecting a fetus is negligible. The user stopped using finasteride during pregnancy and switched to minoxidil and ketoconazole, while others shared experiences and advice on using these treatments safely.

community Possible transgenerational effects of finasteride use on male offspring? (STUDY)

in Research/Science 27 upvotes 4 months ago

Finasteride may affect male offspring's fertility and hormonal balance, with debates on whether to discontinue use before conception. Some users report no issues, while others highlight the high doses used in rat studies.

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Learn

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learn Finasteride

Is finasteride safe? Studies report that most men tolerate finasteride 1 mg, but case series, regulatory labelling and patient reports describe sexual, mood and cognitive effects that some say persisted after stopping, and how often that happens is not established. It is a prescription-only medicine and is contraindicated in pregnancy.
What does finasteride do to the female body? Find out its side effects. Finasteride is not approved for hair loss in women anywhere; the one controlled trial, in 137 postmenopausal women at 1 mg daily, found no benefit over placebo, while smaller uncontrolled studies at higher off-label doses report some improvement. It is contraindicated in pregnancy and crushed or broken tablets must not be handled.
Are there really risks with topical finasteride? Reports on topical finasteride describe scalp irritation and dermatitis as the effects specific to it, and blood levels lower than the oral drug; whether systemic side effects are genuinely rarer has not been measured in a trial powered to answer it. Both forms are prescription-only and contraindicated around pregnancy.
All 4 questions on Finasteride →

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